ArticleBiochemical and biophysical research communications2005
Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein.
Article in Biochemical and biophysical research communications, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Spermidine Confers Liver Protection by Enhancing NRF2 Signaling Through a MAP1S-Mediated Noncanonical Mechanism.Hepatology (Baltimore, Md.) · 2019Article
- Metastatic prostate cancer-associated P62 inhibits autophagy flux and promotes epithelial to mesenchymal transition by sustaining the level of HDAC6.The Prostate · 2018Article
- Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients.Molecular carcinogenesis · 2015Article
- Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin.Aging · 2015Article
- Cell cycle restriction is more important than apoptosis induction for RASSF1A protein tumor suppression.The Journal of biological chemistry · 2014Article
- ABCB1 regulation through LRPPRC is influenced by the methylation status of the GC -100 box in its promoter.Epigenetics · 2014Article
- Article
- Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin.PloS one · 2014Article
- Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability.The Biochemical journal · 2013Article
- RASSF1A: Not a prototypical Ras effector.Small GTPases · 2011Article
- Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation.The Journal of biological chemistry · 2011Article
- PDRG1, a novel tumor marker for multiple malignancies that is selectively regulated by genotoxic stress.Cancer biology & therapy · 2011Article
- Article
- Prestin surface expression and activity are augmented by interaction with MAP1S, a microtubule-associated protein.The Journal of biological chemistry · 2010Article
- Article
- Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells.Oncogene · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
C19ORF5 is a homologue of microtubule-associated protein MAP1B that interacts with natural paclitaxel-like microtubule stabilizer and candidate tumor suppressor RASSF1A. Although normally distributed throughout the cytosol, C19ORF5 specifically associates with microtubules stabilized by paclitaxel or RASSF1A. At sufficiently high concentrations, C19ORF5 causes mitochondrial aggregation and genome destruction (MAGD). The accumulation on hyperstabilized microtubules coupled to MAGD has been proposed to mediate tumor suppression by the taxoid drug family and RASSF1A. Here, we show that the C-terminus of C19ORF5 (C19ORF5C) interacts with mitochondria-associated DNA binding protein, LRPPRC, in liver cells. Like LRPPRC, C19ORF5 also binds DNA with an affinity and specificity sufficient to be of utility in DNA affinity chromatography to purify homogeneous recombinant C19ORF5C from bacterial extracts. Homogeneous C19ORF5 exhibited no intrinsic DNase activity. Deletion mutagenesis indicated that C19ORF5 selectively binds double stranded DNA through its microtubule binding domain. These results suggest C19ORF5 as a DNA binding protein similar to microtubule-associated proteins tau and MAP2.
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