ArticleBMC genomics2005
Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome.
Article in BMC genomics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators.Nature cell biology · 2024Article
- Workflow Optimization for Identification of Female Germline or Oogonial Stem Cells in Human Ovarian Cortex Using Single-Cell RNA Sequence Analysis.Stem cells (Dayton, Ohio) · 2022Article
- A comparative genomic approach using mouse and fruit fly data to discover genes involved in testis function in hymenopterans with a focus on Nasonia vitripennis.BMC ecology and evolution · 2021Article
- Newly Identified Regulators of Ovarian Folliculogenesis and Ovulation.International journal of molecular sciences · 2020Review
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- Genome-wide analysis reveals a switch in the translational program upon oocyte meiotic resumption.Nucleic acids research · 2020Article
- CRISPR/Cas9-Mediated Genome Editing RevealsCells · 2020Article
- An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse.BMC evolutionary biology · 2019Article
- Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Aire-Overexpressing Dendritic Cells Induce Peripheral CD4⁺ T Cell Tolerance.International journal of molecular sciences · 2015Article
- Expression of maternally derived KHDC3, NLRP5, OOEP and TLE6 is associated with oocyte developmental competence in the ovine species.BMC developmental biology · 2014Article
- Cloning and characterization of a novel oocyte-specific gene encoding an F-Box protein in rainbow trout (Oncorhynchus mykiss).Reproductive biology and endocrinology : RB&E · 2013Article
- Stallion sperm transcriptome comprises functionally coherent coding and regulatory RNAs as revealed by microarray analysis and RNA-seq.PloS one · 2013Article
- Transcription factories in the context of the nuclear and genome organization.Nucleic acids research · 2011Review
- Proteome of mouse oocytes at different developmental stages.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Gene clusters, molecular evolution and disease: a speculation.Current genomics · 2009Article
- Search for the genes involved in oocyte maturation and early embryo development in the hen.BMC genomics · 2008Article
- Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.Genetics · 2007Article
- Systematic identification and integrative analysis of novel genes expressed specifically or predominantly in mouse epididymis.BMC genomics · 2006Article
- Role of oocyte-specific genes in the development of mammalian embryos.Reproductive medicine and biology · 2006Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenes specifically expressed in the oocyte play key roles in oogenesis, ovarian folliculogenesis, fertilization and/or early embryonic development. In an attempt to identify novel oocyte-specific genes in the mouse, we have used an in silico subtraction methodology, and we have focused our attention on genes that are organized in genomic clusters.
resultsIn the present work, five clusters have been studied: a cluster of thirteen genes characterized by an F-box domain localized on chromosome 9, a cluster of six genes related to T-cell leukaemia/lymphoma protein 1 (Tcl1) on chromosome 12, a cluster composed of a SPErm-associated glutamate (E)-Rich (Speer) protein expressed in the oocyte in the vicinity of four unknown genes specifically expressed in the testis on chromosome 14, a cluster composed of the oocyte secreted protein-1 (Oosp-1) gene and two Oosp-related genes on chromosome 19, all three being characterized by a partial N-terminal zona pellucida-like domain, and another small cluster of two genes on chromosome 19 as well, composed of a TWIK-Related spinal cord K+ channel encoding-gene, and an unknown gene predicted in silico to be testis-specific. The specificity of expression was confirmed by RT-PCR and in situ hybridization for eight and five of them, respectively. Finally, we showed by comparing all of the isolated and clustered oocyte-specific genes identified so far in the mouse genome, that the oocyte-specific clusters are significantly closer to telomeres than isolated oocyte-specific genes are.
conclusionWe have studied five clusters of genes specifically expressed in female, some of them being also expressed in male germ-cells. Moreover, contrarily to non-clustered oocyte-specific genes, those that are organized in clusters tend to map near chromosome ends, suggesting that this specific near-telomere position of oocyte-clusters in rodents could constitute an evolutionary advantage. Understanding the biological benefits of such an organization as well as the mechanisms leading to a specific oocyte expression in these clusters now requires further investigation.
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