ArticlePLoS biology2005
The pattern of polymorphism in Arabidopsis thaliana.
Article in PLoS biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 476 papers, 1 of them a synthesis that pooled it.
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Who cites it
476 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Genome-Wide SNP Data and Species Distribution Modeling Reveal Population Structure and Conservation Implications ofEcology and evolution · 2026Article
- A comparison of 27 Arabidopsis thaliana genomes and the path toward an unbiased characterization of genetic polymorphism.Nature genetics · 2025Article
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- Transcriptome-referenced association study provides insights into the regulation of oil and fatty acid biosynthesis in Torreya grandis kernel.Journal of advanced research · 2024Article
- High allelic diversity in Arabidopsis NLRs is associated with distinct genomic features.EMBO reports · 2024Article
- Genetic adaptations in the population history of Arabidopsis thaliana.G3 (Bethesda, Md.) · 2023Article
- High intraspecies allelic diversity inbioRxiv : the preprint server for biology · 2023Article
- Metabolome plasticity in 241 Arabidopsis thaliana accessions reveals evolutionary cold adaptation processes.Plant physiology · 2023Article
416 more citing papers are in PubMed but not listed here.
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24 authors.
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Abstract
We resequenced 876 short fragments in a sample of 96 individuals of Arabidopsis thaliana that included stock center accessions as well as a hierarchical sample from natural populations. Although A. thaliana is a selfing weed, the pattern of polymorphism in general agrees with what is expected for a widely distributed, sexually reproducing species. Linkage disequilibrium decays rapidly, within 50 kb. Variation is shared worldwide, although population structure and isolation by distance are evident. The data fail to fit standard neutral models in several ways. There is a genome-wide excess of rare alleles, at least partially due to selection. There is too much variation between genomic regions in the level of polymorphism. The local level of polymorphism is negatively correlated with gene density and positively correlated with segmental duplications. Because the data do not fit theoretical null distributions, attempts to infer natural selection from polymorphism data will require genome-wide surveys of polymorphism in order to identify anomalous regions. Despite this, our data support the utility of A. thaliana as a model for evolutionary functional genomics.
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