ArticleAntimicrobial agents and chemotherapy1992
Effect of an arginine-glycine-aspartic acid-containing peptide on hematogenous candidal infections in rabbits.
Article in Antimicrobial agents and chemotherapy, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Review
- Inhibition of adherence and killing of Candida albicans with a 23-Mer peptide (Fn/23) with dual antifungal properties.Antimicrobial agents and chemotherapy · 2004Article
- Susceptibility to thrombin-induced platelet microbicidal protein is associated with increased fluconazole efficacy against experimental endocarditis due to Candida albicans.Antimicrobial agents and chemotherapy · 2004Article
- Degenerate peptide recognition by Candida albicans adhesins Als5p and Als1p.Infection and immunity · 2004Article
- Cell wall and secreted proteins of Candida albicans: identification, function, and expression.Microbiology and molecular biology reviews : MMBR · 1998Review
- Migration of the fungal pathogen Candida albicans across endothelial monolayers.Infection and immunity · 1996Article
- Resistance to platelet microbicidal protein results in increased severity of experimental Candida albicans endocarditis.Infection and immunity · 1996Article
- Antifungal agents: chemotherapeutic targets and immunologic strategies.Antimicrobial agents and chemotherapy · 1996Review
- Complex interaction between different proteinaceous components within the cell-wall structure of Candida albicans.Mycopathologia · 1995Article
- Comparative study of the C3d receptor and 58-kilodalton fibrinogen-binding mannoproteins of Candida albicans.Infection and immunity · 1995Article
- Evidence for the presence of collagenous domains in Candida albicans cell surface proteins.Infection and immunity · 1995Article
- Adherence of Candida albicans to human buccal epithelial cells: host-induced protein synthesis and signaling events.Infection and immunity · 1995Article
- Binding of the extracellular matrix component entactin to Candida albicans.Infection and immunity · 1994Article
- Murine tissues exposed to cytotoxic drugs display altered patterns of Candida albicans adhesion.Infection and immunity · 1994Article
- Identification and characterization of a Candida albicans-binding proteoglycan secreted from rat submandibular salivary glands.Infection and immunity · 1994Article
- Evidence for the presence of a high-affinity laminin receptor-like molecule on the surface of Candida albicans yeast cells.Infection and immunity · 1994Article
- Adhesins and ligands involved in the interaction of Candida spp. with epithelial and endothelial surfaces.Clinical microbiology reviews · 1994Review
- Evidence that mannans of Candida albicans are responsible for adherence of yeast forms to spleen and lymph node tissue.Infection and immunity · 1993Article
- Expression of the complement-binding protein (MP60) of Candida albicans in experimental vaginitis.MycopathologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adherence of Candida albicans yeast cells to the subendothelial extracellular matrix, fibronectin, laminin, and type I and IV collagen was tested. Fibronectin (10(-7) M) and a peptide, PepTite-2000 (Telios Pharmaceuticals Inc., San Diego, Calif.), containing the sequence arginine-glycine-aspartic acid (RGD) inhibited Candida adherence to these targets by greater than 90%. When C. albicans was perfused over ex vivo rabbit aortic endothelium, there was no significant difference in the amount of adherence in the presence or absence of the RGD-containing peptide. However, the RGD-containing peptide reduced the number of Candida organisms present in liver, brain, heart, and kidneys (P less than 0.05) of rabbits 4 h after intravenous inoculation of 5 x 10(7) C. albicans yeast cells. The peptide also reduced the number of macroscopic Candida abscesses in the kidneys of rabbits 72 h after intravenous inoculation of 10(7) C. albicans yeast cells (P less than 0.05). Inhibition of Candida adherence in vitro and in vivo may occur because the peptide blocks a fungal receptor that is necessary for adherence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.