ArticleProceedings. Biological sciences2005
MHC odours are not required or sufficient for recognition of individual scent owners.
Article in Proceedings. Biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Dynamic changes to signal allocation rules in response to variable social environments in house mice.Communications biology · 2023Article
- Dynamic influences on the neural encoding of social valence.Nature reviews. Neuroscience · 2022Review
- Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals.Scientific reports · 2021Article
- Individual odour signatures that mice learn are shaped by involatile major urinary proteins (MUPs).BMC biology · 2018Article
- Experimenter effects on behavioral test scores of eight inbred mouse strains under the influence of ethanol.Behavioural brain research · 2014Article
- Of volatiles and peptides: in search for MHC-dependent olfactory signals in social communication.Cellular and molecular life sciences : CMLS · 2014Review
- Sexual attractiveness of male chemicals and vocalizations in mice.Frontiers in neuroscience · 2014Review
- Are mammal olfactory signals hiding right under our noses?Die Naturwissenschaften · 2013Review
- MHC signaling during social communication.Advances in experimental medicine and biology · 2012Article
- Mouse models of autism: testing hypotheses about molecular mechanisms.Current topics in behavioral neurosciences · 2011Article
- Paternal recognition of adult offspring mediated by newly generated CNS neurons.Nature neuroscience · 2010Article
- Social features of scent-donor mice modulate scent marking of C57BL/6J recipient males.Behavioural brain research · 2009Article
- Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia.Pharmacology & therapeutics · 2009Review
- Cryptic preference for MHC-dissimilar females in male red junglefowl, Gallus gallus.Proceedings. Biological sciences · 2009Article
- Housing conditions and stimulus females: a robust social discrimination task for studying male rodent social recognition.Nature protocols · 2009Article
- Ant queen egg-marking signals: matching deceptive laboratory simplicity with natural complexity.PloS one · 2009Article
- Scent marking behavior as an odorant communication in mice.Neuroscience and biobehavioral reviews · 2008Review
- A new test paradigm for social recognition evidenced by urinary scent marking behavior in C57BL/6J mice.Behavioural brain research · 2008Article
- Self-referent MHC type matching in frog tadpoles.Proceedings. Biological sciences · 2008Article
- Chemical characterization of territorial marking fluid of male Bengal tiger, Panthera tigris.Journal of chemical ecology · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
To provide information about specific depositors, scent marks need to encode a stable signal of individual ownership. The highly polymorphic major histocompatibility complex (MHC) influences scents and contributes to the recognition of close kin and avoidance of inbreeding when MHC haplotypes are shared. MHC diversity between individuals has also been proposed as a primary source of scents used in individual recognition. We tested this in the context of scent owner recognition among male mice, which scent mark their territories and countermark scents from other males. We examined responses towards urine scent according to the scent owner's genetic difference to the territory owner (MHC, genetic background, both and neither) or genetic match to a familiar neighbour. While urine of a different genetic background from the subject always stimulated greater scent marking than own, regardless of familiarity, MHC-associated odours were neither necessary nor sufficient for scent owner recognition and failed to stimulate countermarking. Urine of a different MHC type to the subject stimulated increased investigation only when this matched both the MHC and genetic background of a familiar neighbour. We propose an associative model of scent owner recognition in which volatile scent profiles, contributed by both fixed genetic and varying non-genetic factors, are learnt in association with a stable involatile ownership signal provided by other highly polymorphic urine components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.