Trial reportGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2005
Effect of intravitreal dexamethasone on vitreous vancomycin concentrations in patients with suspected postoperative bacterial endophthalmitis.
Trial report in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Visual outcomes of acute bacterial endophthalmitis treated with adjuvant intravitreal dexamethasone: A meta-analysis and systematic review.Indian journal of ophthalmology · 2022Pooled it
- Intravitreal dexamethasone as adjuvant in the treatment of postoperative endophthalmitis: a prospective randomized trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2005Trial
- Suprachoroidal implantation of corticosteroid slow release implants for the treatment of cystoid macular edema.Scientific reports · 2025Article
- Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Magnetically Controlled Intraocular Delivery of Dexamethasone Using Silica-Coated Magnetic Nanoparticles.ACS omega · 2024Article
- An intravitreal implant injection method for sustained drug delivery into mouse eyes.Cell reports methods · 2021Article
- Long-term visual outcomes of endophthalmitis and the role of systemic steroids in addition to intravitreal dexamethasone.BMC ophthalmology · 2020Article
- Targets of immunomodulation in bacterial endophthalmitis.Progress in retinal and eye research · 2019Review
- A Review of the Role of Intravitreal Corticosteroids as an Adjuvant to Antibiotics in Infectious Endophthalmitis.Ocular immunology and inflammation · 2018Review
- Comparison of the Effect of Intravitreal Dexamethasone Implant in Vitrectomized and Nonvitrectomized Eyes for the Treatment of Diabetic Macular Edema.Journal of ophthalmology · 2018Article
- Pharmacokinetics and efficacy of intraocular flurbiprofen.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Article
- New Drugs and New Posterior Delivery Methods in CME.Current ophthalmology reports · 2017Article
- Persistently Vitreous Culture-Positive Exogenous Bacterial Endophthalmitis.American journal of ophthalmology · 2016Article
- Role of implants in the treatment of diabetic macular edema: focus on the dexamethasone intravitreal implant.Diabetes, metabolic syndrome and obesity : targets and therapy · 2015Review
- Intravitreal controlled release of dexamethasone from engineered microparticles of porous silicon dioxide.Experimental eye research · 2014Article
- Steroid differentiation: the safety profile of various steroids on retinal cells in vitro and their implications for clinical use (an American Ophthalmological Society thesis).Transactions of the American Ophthalmological Society · 2014Article
- Evidence for and against intravitreous corticosteroids in addition to intravitreous antibiotics for acute endophthalmitis.International ophthalmology clinics · 2014Review
- Pharmacokinetics of intravitreal antibiotics in endophthalmitis.Journal of ophthalmic inflammation and infection · 2014Review
- The therapeutic potential of intraocular depot steroid systems: developments aimed at prolonging duration of efficacy.Deutsches Arzteblatt international · 2012Review
- Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: host-microbe interactions in intraocular infection.Progress in retinal and eye research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study intravitreal dexamethasone and vancomycin concentrations, when used together in patients with suspected postoperative bacterial endophthalmitis. Animal studies had suggested that dexamethasone might decrease the concentration of vancomycin.
designProspective randomized clinical trial in a tertiary referral center.
methodsTwenty-nine consecutive patients with suspected postoperative bacterial endophthalmitis underwent a vitreous biopsy followed by intravitreal injection of antibiotics (0.2 mg vancomycin, 0.05 mg gentamicin) and 400 mug dexamethasone or placebo. After 3-4 days, the intravitreal injection of antibiotics and dexamethasone or placebo was repeated. In 18 patients, a second biopsy was taken for repeat culture and measurement of vancomycin and dexamethasone concentrations.
resultsIn 20/29 patients (69%) the first vitreous cultures were positive; the second culture was negative in all cases. Thirteen out of 29 patients received dexamethasone. Dexamethasone concentrations showed an average of 25 ng/ml 3 days after injection, with an estimated half-life of 5.5 h. Vancomycin concentrations in patients given dexamethasone tended to be higher compared with those in the placebo group (P=0.061).
conclusionIntravitreal dexamethasone does not lead to decreased vancomycin concentrations, when given simultaneously in the treatment of patients with suspected bacterial endophthalmitis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.