ArticleNucleic acids research2005
Magnetically assisted DNA assays: high selectivity using conjugated polymers for amplified fluorescent transduction.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Prospects and challenges of dynamic DNA nanostructures in biomedical applications.Bone research · 2022Review
- Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging.Chemical science · 2015Article
- The concept of λ-ratiometry in fluorescence sensing and imaging.Journal of fluorescence · 2010Review
- Single-nucleotide polymorphism (SNP) genotyping using cationic conjugated polymers in homogeneous solution.Nature protocols · 2009Article
- Maximizing DNA loading on a range of gold nanoparticle sizes.Analytical chemistry · 2006Article
- Potential diagnostic applications of biosensors: current and future directions.International journal of nanomedicine · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a strategy for conjugated polymer (CP)-based optical DNA detection with improved selectivity. The high sensitivity of CP-based biosensors arises from light harvesting by the CP and the related amplified fluorescent signal transduction. We demonstrate that the use of magnetic microparticles significantly improves the selectivity of this class of DNA sensors. Compared with previously reported DNA sensors with CP amplification, this novel sensing strategy displays excellent discrimination against non-cognate DNA in the presence of a protein mixture or even human serum. We also demonstrate that the magnetically assisted DNA sensor can conveniently identify even a single-nucleotide mismatch in the target sequence.
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Registered trials
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