ArticleGenes & development2005
Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 101 citations in OpenAlex.
- Evolvability in vertebrate segmentation.Seminars in cell & developmental biology · 2025Review
- Temporal and Spatial Variations in ZebrafishInternational journal of molecular sciences · 2024Article
- Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024Review
- Oscillatory control of embryonic development.Development (Cambridge, England) · 2024Review
- Effects of microRNA-305 knockdown on brain gene expression associated with division of labor in honey bee colonies (Apis mellifera).The Journal of experimental biology · 2024Article
- Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes.Nature communications · 2023Article
- Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation.Nature communications · 2023Article
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
- Review
- Article
- The kinetics in mathematical models on segmentation clock genes in zebrafish.Journal of mathematical biology · 2018Article
- Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling.BioMed research international · 2018Article
- Delta-Notch signalling in segmentation.Arthropod structure & development · 2017Review
- Signalling dynamics in vertebrate segmentation.Nature reviews. Molecular cell biology · 2014Review
- Caudal regulates the spatiotemporal dynamics of pair-rule waves in Tribolium.PLoS genetics · 2014Article
- Article
- Single-cell-resolution imaging of the impact of Notch signaling and mitosis on segmentation clock dynamics.Developmental cell · 2012Article
- The synchrony and cyclicity of developmental events.Cold Spring Harbor perspectives in biology · 2012Article
- A novel zebrafish embryo xenotransplantation model to study primary human fibroblast motility in health and disease.Zebrafish · 2012Article
- The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub.Development (Cambridge, England) · 2012Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Notch and fibroblast growth factor (FGF) signaling pathways have been implicated in the establishment of proper periodicity of vertebrate somites. Here, we show evidence that a Hes6-related hairy/Enhancer of split-related gene, her13.2, links FGF signaling to the Notch-regulated oscillation machinery in zebrafish. Expression of her13.2 is induced by FGF-soaked beads and decreased by an FGF signaling inhibitor. her13.2 is required for periodic repression of the Notch-regulated genes her1 and her7, and for proper somite segmentation. Furthermore, Her13.2 augments autorepression of her1 in association with Her1 protein. Therefore, FGF signaling appears to maintain the oscillation machinery by supplying a binding partner, Her13.2, for Her1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.