ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2005
Response of membrane potential and intracellular pH to hypercapnia in neurons and astrocytes from rat retrotrapezoid nucleus.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 77 citations in OpenAlex.
- Review
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- Phox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models.Nature communications · 2023Article
- Breathing in Duchenne muscular dystrophy: translation to therapy.The Journal of physiology · 2022Review
- Central respiratory chemoreception.Handbook of clinical neurology · 2022Review
- KGlia · 2021Article
- Bicarbonate directly modulates activity of chemosensitive neurons in the retrotrapezoid nucleus.The Journal of physiology · 2018Article
- Theoretical perspectives on central chemosensitivity: CO2/H+-sensitive neurons in the locus coeruleus.PLoS computational biology · 2017Article
- Mechanisms of CO2/H+ Sensitivity of Astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Respiratory and autonomic dysfunction in congenital central hypoventilation syndrome.Journal of neurophysiology · 2016Review
- Anatomical and functional connections between the locus coeruleus and the nucleus tractus solitarius in neonatal rats.Neuroscience · 2016Article
- Role of the retrotrapezoid nucleus/parafacial respiratory group in coughing and swallowing in guinea pigs.Journal of neurophysiology · 2015Article
- HCN channels contribute to serotonergic modulation of ventral surface chemosensitive neurons and respiratory activity.Journal of neurophysiology · 2015Article
- Regulation of breathing and autonomic outflows by chemoreceptors.Comprehensive Physiology · 2014Review
- Substance P differentially modulates firing rate of solitary complex (SC) neurons from control and chronic hypoxia-adapted adult rats.PloS one · 2014Article
- Transient outwardly rectifying A currents are involved in the firing rate response to altered CO2 in chemosensitive locus coeruleus neurons from neonatal rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling.The Journal of physiology · 2012Article
- Redefining the components of central CO2 chemosensitivity--towards a better understanding of mechanism.The Journal of physiology · 2011Review
- CO2-dependent opening of an inwardly rectifying K+ channel.Pflugers Archiv : European journal of physiology · 2011Article
- Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism.Journal of neurophysiology · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We compared the response to hypercapnia (10%) in neurons and astrocytes among a distinct area of the retrotrapezoid nucleus (RTN), the mediocaudal RTN (mcRTN), and more intermediate and rostral RTN areas (irRTN) in medullary brain slices from neonatal rats. Hypercapnic acidosis (HA) caused pH(o) to decline from 7.45 to 7.15 and a maintained intracellular acidification of 0.15 +/- 0.02 pH unit in 90% of neurons from both areas (n = 16). HA excited 44% of mcRTN (7/16) and 38% of irRTN neurons (6/16), increasing firing rate by 167 +/- 75% (chemosensitivity index, CI, 256 +/- 72%) and 310 +/- 93% (CI 292 +/- 50%), respectively. These responses did not vary throughout neonatal development. We compared the responses of mcRTN neurons to HA (decreased pH(i) and pH(o)) and isohydric hypercapnia (IH; decreased pH(i) with constant pH(o)). Neurons excited by HA (firing rate increased 156 +/- 46%; n = 5) were similarly excited by IH (firing rate increased 167 +/- 38%; n = 5). In astrocytes from both RTN areas, HA caused a maintained intracellular acidification of 0.17 +/- 0.02 pH unit (n = 6) and a depolarization of 5 +/- 1 mV (n = 12). In summary, many neurons (42%) from the RTN are highly responsive (CI 248%) to HA; this may reflect both synaptically driven and intrinsic mechanisms of CO(2) sensitivity. Changes of pH(i) are more significant than changes of pH(o) in chemosensory signaling in RTN neurons. Finally, the lack of pH(i) regulation in response to HA suggests that astrocytes do not enhance extracellular acidification during hypercapnia in the RTN.
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