ArticleBiochimica et biophysica acta2005
Antimicrobial activity and membrane selective interactions of a synthetic lipopeptide MSI-843.
Article in Biochimica et biophysica acta, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- How to Combat Gram-Negative Bacteria Using Antimicrobial Peptides: A Challenge or an Unattainable Goal?Antibiotics (Basel, Switzerland) · 2021Review
- pH-Dependent Conformations of an Antimicrobial Spider Venom Peptide, Cupiennin 1a, from Unbiased HREMD Simulations.ACS omega · 2021Article
- Shorter Antibacterial Peptide Having High Selectivity forMicroorganisms · 2020Article
- Review
- Structural insights into the combinatorial effects of antimicrobial peptides reveal a role of aromatic-aromatic interactions in antibacterial synergism.The Journal of biological chemistry · 2019Article
- Small AntiMicrobial Peptide With in Vivo Activity Against Sepsis.Molecules (Basel, Switzerland) · 2019Article
- Impact of membrane curvature on amyloid aggregation.Biochimica et biophysica acta. Biomembranes · 2018Review
- In Silico Discovery of Novel Ligands for Antimicrobial Lipopeptides for Computer-Aided Drug Design.Probiotics and antimicrobial proteins · 2018Review
- Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens.PloS one · 2018Article
- Engineering a Novel Porin OmpGF Via Strand Replacement from Computational Analysis of Sequence Motif.Biochimica et biophysica acta. Biomembranes · 2017Article
- Influence of Amphibian Antimicrobial Peptides and Short Lipopeptides on Bacterial Biofilms Formed on Contact Lenses.Materials (Basel, Switzerland) · 2016Article
- Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine.PloS one · 2016Article
- Nature-inspired antimicrobial polymers--assessment of their potential for biomedical applications.PloS one · 2013Article
- Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?Biochimica et biophysica acta · 2012Article
- Initial efforts toward the optimization of arylomycins for antibiotic activity.Journal of medicinal chemistry · 2011Article
- The potential of antimicrobial peptides as biocides.International journal of molecular sciences · 2011Review
- Limiting an antimicrobial peptide to the lipid-water interface enhances its bacterial membrane selectivity: a case study of MSI-367.Biochemistry · 2010Article
- A miniature mimic of host defense peptides with systemic antibacterial efficacy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Probing the "charge cluster mechanism" in amphipathic helical cationic antimicrobial peptides.Biochemistry · 2010Article
- Cell-wall interactions and the selective bacteriostatic activity of a miniature oligo-acyl-lysyl.Biophysical journal · 2009Article
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Authors and funding
5 authors.
Funding
Abstract
Lipopeptide MSI-843 consisting of the nonstandard amino acid ornithine (Oct-OOLLOOLOOL-NH2) was designed with an objective towards generating non-lytic short antimicrobial peptides, which can have significant pharmaceutical applications. Octanoic acid was coupled to the N-terminus of the peptide to increase the overall hydrophobicity of the peptide. MSI-843 shows activity against bacteria and fungi at micromolar concentrations. It permeabilizes the outer membrane of Gram-negative bacterium and a model membrane mimicking bacterial inner membrane. Circular dichroism investigations demonstrate that the peptide adopts alpha-helical conformation upon binding to lipid membranes. Isothermal titration calorimetry studies suggest that the peptide binding to membranes results in exothermic heat of reaction, which arises from helix formation and membrane insertion of the peptide. 2H NMR of deuterated-POPC multilamellar vesicles shows the peptide-induced disorder in the hydrophobic core of bilayers. 31P NMR data indicate changes in the lipid head group orientation of POPC, POPG and Escherichia colitotal lipid bilayers upon peptide binding. Results from 31P NMR and dye leakage experiments suggest that the peptide selectively interacts with anionic bilayers at low concentrations (up to 5 mol%). Differential scanning calorimetry experiments on DiPOPE bilayers and 31P NMR data from E.coli total lipid multilamellar vesicles indicate that MSI-843 increases the fluid lamellar to inverted hexagonal phase transition temperature of bilayers by inducing positive curvature strain. Combination of all these data suggests the formation of a lipid-peptide complex resulting in a transient pore as a plausible mechanism for the membrane permeabilization and antimicrobial activity of the lipopeptide MSI-843.
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