ReviewDrugs & aging2005
Predicting and preventing adverse drug reactions in the very old.
Review in Drugs & aging, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.
- Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: diagnosis and management.The Canadian journal of cardiology · 2006Guideline
- Reduction in targeted potentially inappropriate medication use in elderly inpatients: a pragmatic randomized controlled trial.European journal of clinical pharmacology · 2017Trial
- Identifying and preventing adverse drug events in elderly hospitalised patients: a randomised trial of a program to reduce adverse drug effects.The journal of nutrition, health & aging · 2010Trial
- Article
- Adverse drug reactions and events in an Ageing PopulaTion risk Prediction (ADAPTiP) tool: the development and validation of a model for predicting adverse drug reactions and events in older patients.European geriatric medicine · 2025Article
- Transdermal Fentanyl Patch Effectiveness in Postoperative PainManagement in Orthopedic Patients: Literature Review.Journal of clinical medicine · 2024Review
- The Association Between Medication Use in Older Women with Early-Stage Operable Primary Breast Cancer and Decision Regarding Primary Treatment.The oncologist · 2023Article
- Observational
- Under-prescription of medications in older adults according to START criteria: A cross-sectional study in Lebanon.Health science reports · 2022Article
- REview of potentially inappropriate MEDIcation pr[e]scribing in Seniors (REMEDI[e]S): French implicit and explicit criteria.European journal of clinical pharmacology · 2021Article
- Mapping of drug-related problems among older adults conciliating medical and pharmaceutical approaches.European geriatric medicine · 2021Review
- Anticholinergic Burden and Safety Outcomes in Older Patients with Chronic Hepatitis C: A Retrospective Cohort Study.International journal of environmental research and public health · 2020Observational
- The Risk of Drug-Drug Interactions with Paracetamol in a Population of Hospitalized Geriatric Patients.Journal of pharmaceutics · 2020Article
- Incidence Rate of Hypersensitivity Reactions to Bee-Venom Acupuncture.Frontiers in pharmacology · 2020Article
- Effects of stratified medication review in high-risk patients at admission to hospital: a randomised controlled trial.Therapeutic advances in drug safety · 2020Article
- Medication errors in emergency departments: is electronic medical record an effective barrier?Einstein (Sao Paulo, Brazil) · 2019Article
- A pharmacist-physician intervention model using a computerized alert system to reduce high-risk medication use in primary care.European journal of clinical pharmacology · 2019Article
- Article
- Opioid Use and Pain Control in the Elderly After Elective or Urgent Orthopaedic Surgery: A Retrospective Cohort Study.Clinical drug investigation · 2019Article
- A Pharmacist-Led Transitional Care Program to Reduce Hospital Readmissions in Older Adults.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The size of the elderly population has been increasing steadily for several years. Individuals in this age group often have several concomitant diseases that require treatment with multiple medications. These drugs, for various reasons and especially as a consequence of potential accumulation, may be associated with adverse reactions. Of the numerous factors that can favour the occurrence of these adverse drug reactions, the most important are the pathophysiological consequences of aging, particularly as these apply to the very old. Although absorption of drugs is not usually reduced in the elderly, diffusion, distribution and particularly elimination decline with age. Furthermore, while hepatic metabolic function is fairly normal, renal function is usually markedly depressed in very old individuals, and this can translate into clinical consequences if it is not taken into account. This is why, before administration of any drug in the elderly, evaluation of glomerular filtration rate is essential. Validated estimations such as those obtained from the classical Cockcroft-Gault formula or from more recent methodologies are required. In addition to reductions in various organ functions, factors connected with very old age such as frailty, falls, abnormal sensitivity to medications and polypathology, all of which tend to be more common in the last years of life, all directly impact on adverse drug reaction occurrence. Given these characteristics of the elderly population, the best way to reduce the prevalence of adverse drug reactions in this group is to limit drug prescription to essential medications, make sure that use of prescribed agents is clearly explained to the patient, give drugs for as short a period as possible, and periodically re-evaluate all use of drugs in the elderly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.