ArticleThe EMBO journal2005
Homologous recombination is involved in transcription-coupled repair of UV damage in Saccharomyces cerevisiae.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Green tea extract promotes DNA repair in a yeast model.Scientific reports · 2019Article
- The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions.PLoS neglected tropical diseases · 2018Article
- Histone H3 K79 methylation states play distinct roles in UV-induced sister chromatid exchange and cell cycle checkpoint arrest in Saccharomyces cerevisiae.Nucleic acids research · 2014Article
- A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.Cell reports · 2013Article
- In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae.BMC systems biology · 2013Article
- The role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis.International journal of molecular sciences · 2013Review
- EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases.Molecular genetics and genomics : MGG · 2011Article
- Role of the homologous recombination genes RAD51 and RAD59 in the resistance of Candida albicans to UV light, radiomimetic and anti-tumor compounds and oxidizing agents.Fungal genetics and biology : FG & B · 2010Article
- Rad10 exhibits lesion-dependent genetic requirements for recruitment to DNA double-strand breaks in Saccharomyces cerevisiae.Nucleic acids research · 2009Article
- A single amino acid change in histone H4 enhances UV survival and DNA repair in yeast.Nucleic acids research · 2008Article
- Article
- Transcription of Satellite III non-coding RNAs is a general stress response in human cells.Nucleic acids research · 2008Article
- Cockayne syndrome group B protein has novel strand annealing and exchange activities.Nucleic acids research · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To efficiently protect the integrity of genetic information, transcription is connected to nucleotide excision repair (NER), which allows preferential repair of the transcribed DNA strands (TS). As yet, the molecular basis of this connection remains elusive in eukaryotic cells. Here we show that, in haploids, the RAD26 gene is essential for the preferential repair of the TS during G1. However, in G2/M phase there is an additional RAD51-dependent process that enhances repair of TS. Importantly, the simultaneous deletion of both RAD26 and RAD51 led to complete abolishment of strand-specific repair during G2/M, indicating that these genes act through two independent but complementary subpathways. In diploids, however, RAD51 is involved in repair of the TS even in G1 phase, which unveils the implication of homologous recombination in the preferential repair of the TS. Importantly, the abolishment of NER, by abrogation of RAD1 or RAD14, completely stopped repair of UV damage even during G2/M phase. These results show the existence of functional cross-talk between transcription, homologous recombination and NER.
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