ArticleProceedings of the National Academy of Sciences of the United States of America2005
Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Antigen presentation of post-translationally modified peptides in major histocompatibility complexes.Immunology and cell biology · 2025Review
- Structural aspects of chemical modifications in the MHC-restricted immunopeptidome; Implications for immune recognition.Frontiers in chemistry · 2022Review
- An immunohistochemical study of nitrotyrosine expression in pancreatic islets of cases with increasing duration of type 1 diabetes and without diabetes.Histochemistry and cell biology · 2017Article
- On Peptides and Altered Peptide Ligands: From Origin, Mode of Action and Design to Clinical Application (Immunotherapy).International archives of allergy and immunology · 2016Review
- Perception of self: distinguishing autoimmunity from autoinflammation.Nature reviews. Rheumatology · 2015Review
- Self-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCs.Molecular immunology · 2015Article
- Molecules in medicine mini review: the αβ T cell receptor.Journal of molecular medicine (Berlin, Germany) · 2014Review
- Unconventional post-translational modifications in immunological signaling.Nature immunology · 2014Review
- The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment.Frontiers in immunology · 2014Review
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- Epithelial, dendritic, and CD4(+) T cell regulation of and by reactive oxygen and nitrogen species in allergic sensitization.Biochimica et biophysica acta · 2011Review
- Regulation of CD4 T-cell receptor diversity by vaccine adjuvants.Immunology · 2010Review
- Post-translationally modified T cell epitopes: immune recognition and immunotherapy.Journal of molecular medicine (Berlin, Germany) · 2009Review
- Identification of immunoglobulins that recognize 3-nitrotyrosine in patients with acute lung injury after major trauma.American journal of respiratory cell and molecular biology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD4 T cells recognized posttranslationally modified peptides of the protein hen egg-white lysozyme (HEL), consisting of nitration of tyrosines and modifications of tryptophans in the T cell contact residues of the peptides. T cells were directed against modifications of a chemically dominant HEL peptide as well as a minor HEL peptide, bound to the class II histocompatibility molecule I-A(k). The modified peptides were generated in vivo after immunization with native HEL molecules or were generated ex vivo by peroxynitrite treatment of HEL. Moreover, antigen-presenting cells (APC), either macrophages or dendritic cells activated in culture or in vivo, generated the modified HEL epitopes that stimulated the T cells. In transgenic mice expressing HEL, the T cells to the modified epitopes escaped negative selection and were found, albeit fewer in number than in normal mice. Infection with Listeria monocytogenes of the transgenic HEL mice generated APC containing the modifications. T cells to modified epitopes induced by activation of APC may be a component of antimicrobial immunity and autoimmune reactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.