ArticleMolecular biology of the cell2005
Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Endocytosis at the Crossroad of Polarity and Signaling Regulation: Learning fromInternational journal of molecular sciences · 2022Review
- Phosphatidic acid increases Notch signalling by affecting Sanpodo trafficking during Drosophila sensory organ development.Scientific reports · 2020Article
- The Dlg Module and Clathrin-Mediated Endocytosis Regulate EGFR Signaling and Cyst Cell-Germline Coordination in the Drosophila Testis.Stem cell reports · 2019Article
- Article
- Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases.Advances in experimental medicine and biology · 2018Review
- Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells.Molecular biology of the cell · 2016Article
- Lethal (2) giant larvae: an indispensable regulator of cell polarity and cancer development.International journal of biological sciences · 2015Review
- Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor.Cell cycle (Georgetown, Tex.) · 2015Article
- Sanpodo controls sensory organ precursor fate by directing Notch trafficking and binding γ-secretase.The Journal of cell biology · 2013Article
- Endocytosis and control of Notch signaling.Current opinion in cell biology · 2012Review
- Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells.The Journal of biological chemistry · 2012Article
- Endocytosis by Numb breaks Notch symmetry at cytokinesis.Nature cell biology · 2012Article
- dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions.The Journal of cell biology · 2012Article
- Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Physiological reviews · 2012Review
- Differential regulation of adherens junction dynamics during apical-basal polarization.Journal of cell science · 2011Article
- Golgi during development.Cold Spring Harbor perspectives in biology · 2011Review
- Numb independently antagonizes Sanpodo membrane targeting and Notch signaling in Drosophila sensory organ precursor cells.Molecular biology of the cell · 2010Article
- Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis.Development (Cambridge, England) · 2010Article
- Endocytosis and intracellular trafficking of Notch and its ligands.Current topics in developmental biology · 2010Review
- Endocytic regulation of Notch signaling.Current opinion in genetics & development · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, asymmetric division occurs during proliferation of neural precursors of the central and peripheral nervous system (PNS), where a membrane-associated protein, Numb, is asymmetrically localized during cell division and is segregated to one of the two daughter cells (the pIIb cell) after mitosis. numb has been shown genetically to function as an antagonist of Notch signaling and also as a negative regulator of the membrane localization of Sanpodo, a four-pass transmembrane protein required for Notch signaling during asymmetric cell division in the CNS. Previously, we identified lethal giant larvae (lgl) as a gene required for numb-mediated inhibition of Notch in the adult PNS. In this study we show that Sanpodo is expressed in asymmetrically dividing precursor cells of the PNS and that Sanpodo internalization in the pIIb cell is dependent cytoskeletally associated Lgl. Lgl specifically regulates internalization of Sanpodo, likely through endocytosis, but is not required for the endocytosis Delta, which is a required step in the Notch-mediated cell fate decision during asymmetric cell division. Conversely, the E3 ubiquitin ligase neuralized is required for both Delta endocytosis and the internalization of Sanpodo. This study identifies a hitherto unreported role for Lgl as a regulator of Sanpodo during asymmetric cell division in the adult PNS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.