ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
The functional divide for primary reinforcement of D-amphetamine lies between the medial and lateral ventral striatum: is the division of the accumbens core, shell, and olfactory tubercle valid?
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
70 citing papers in PubMed, 122 citations in OpenAlex.
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.bioRxiv : the preprint server for biology · 2025Article
- Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life.Frontiers in neural circuits · 2024Review
- Dopamine Modulates the Processing of Food Odour in the Ventral Striatum.Biomedicines · 2022Article
- Article
- Genetically identified amygdala-striatal circuits for valence-specific behaviors.Nature neuroscience · 2021Article
- Connectivity characterization of the mouse basolateral amygdalar complex.Nature communications · 2021Article
- The tubular striatum and nucleus accumbens distinctly represent reward-taking and reward-seeking.Journal of neurophysiology · 2021Article
- Involvement of cAMP-Dependent Protein Kinase in the Nucleus Accumbens in Cocaine Versus Social Interaction Reward.International journal of molecular sciences · 2020Article
- Neural and Hormonal Control of Sexual Behavior.Endocrinology · 2020Review
- The Mesolimbic Dopamine Activity Signatures of Relapse to Alcohol-Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neurochemical organization of the ventral striatum's olfactory tubercle.Journal of neurochemistry · 2020Review
- Hypothetical Roles of the Olfactory Tubercle in Odor-Guided Eating Behavior.Frontiers in neural circuits · 2020Review
- Relative contributions and mapping of ventral tegmental area dopamine and GABA neurons by projection target in the rat.The Journal of comparative neurology · 2019Article
- Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography.Frontiers in neuroscience · 2019Article
- Central GLP-1 receptor activation modulates cocaine-evoked phasic dopamine signaling in the nucleus accumbens core.Physiology & behavior · 2017Article
- Functional Sub-Circuits of the Olfactory System Viewed from the Olfactory Bulb and the Olfactory Tubercle.Frontiers in neuroanatomy · 2017Review
- Role of projections from ventral subiculum to nucleus accumbens shell in context-induced reinstatement of heroin seeking in rats.Psychopharmacology · 2016Article
- The Neural Representation of Goal-Directed Actions and Outcomes in the Ventral Striatum's Olfactory Tubercle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Basal ganglia circuit loops, dopamine and motivation: A review and enquiry.Behavioural brain research · 2015Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
When projection analyses placed the nucleus accumbens and olfactory tubercle in the striatal system, functional links between these sites began to emerge. The accumbens has been implicated in the rewarding effects of psychomotor stimulants, whereas recent work suggests that the medial accumbens shell and medial olfactory tubercle mediate the rewarding effects of cocaine. Interestingly, anatomical evidence suggests that medial portions of the shell and tubercle receive afferents from common zones in a number of regions. Here, we report results suggesting that the current division of the ventral striatum into the accumbens core and shell and the olfactory tubercle does not reflect the functional organization for amphetamine reward. Rats quickly learned to self-administer D-amphetamine into the medial shell or medial tubercle, whereas they failed to learn to do so into the accumbens core, ventral shell, or lateral tubercle. Our results suggest that primary reinforcement of amphetamine is mediated via the medial portion of the ventral striatum. Thus, the medial shell and medial tubercle are more functionally related than the medial and ventral shell or the medial and lateral tubercle. The current core-shell-tubercle scheme should be reconsidered in light of recent anatomical data and these functional findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.