ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Modulation of presynaptic Ca2+ entry by AMPA receptors at individual GABAergic synapses in the cerebellum.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed.
- Ethanol disrupts cerebellar synaptic modulation by enhancing EAAT4-mediated glutamate uptake.Communications biology · 2026Article
- Afferent convergence to a shared population of interneuron AMPA receptors.Nature communications · 2023Article
- Review
- Assessment of Paroxetine Molecular Interactions with Selected Monoamine and γ-Aminobutyric Acid Transporters.International journal of molecular sciences · 2021Article
- Fluorescence lifetime imaging reveals regulation of presynaptic CaJournal of neurochemistry · 2021Article
- Current Techniques for Investigating the Brain Extracellular Space.Frontiers in neuroscience · 2020Review
- Synaptic function and plasticity in identified inhibitory inputs onto VTA dopamine neurons.The European journal of neuroscience · 2018Article
- Transmembrane AMPAR regulatory protein γ-2 is required for the modulation of GABA release by presynaptic AMPARs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Neuronal adaptation involves rapid expansion of the action potential initiation site.Nature communications · 2014Article
- Alterations in the intrinsic burst activity of Purkinje neurons in offspring maternally exposed to the CB1 cannabinoid agonist WIN 55212-2.The Journal of membrane biology · 2014Article
- The betaine/GABA transporter and betaine: roles in brain, kidney, and liver.Frontiers in physiology · 2014Review
- Comparison of Ca2+ transients and [Ca2+]i in the dendrites and boutons of non-fast-spiking GABAergic hippocampal interneurons using two-photon laser microscopy and high- and low-affinity dyes.The Journal of physiology · 2013Article
- A role of TARPs in the expression and plasticity of calcium-permeable AMPARs: evidence from cerebellar neurons and glia.Neuropharmacology · 2013Review
- The Cav3-Kv4 complex acts as a calcium sensor to maintain inhibitory charge transfer during extracellular calcium fluctuations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Functional integration of calcium regulatory mechanisms at Purkinje neuron synapses.Cerebellum (London, England) · 2012Review
- Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice.Epilepsy research · 2011Article
- Axonal GABAA receptors increase cerebellar granule cell excitability and synaptic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Neurotransmitter release during delay eyeblink classical conditioning: role of norepinephrine in consolidation and effect of age.Neurobiology of learning and memory · 2009Article
- Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum.Neuroscience · 2009Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cerebellar Purkinje cells (PCs) receive GABAergic input that undergoes powerful retrograde modulation by presynaptic cannabinoid and glutamate receptors. Here we examine a distinct modulatory mechanism at these synapses, which does not require postsynaptic depolarization and acts via presynaptic AMPA receptors. We find that this mechanism operates mainly in the somatic vicinity of PCs in which large boutons of basket cell axons form synapses on the PC soma. We use fast confocal microscopy and detailed kinetic modeling to estimate that, in these boutons, an action potential opens 100-200 Ca2+ channels, eliciting a brief 3-5 microM transient, followed by a longer-term, 15-30 nM rise of free Ca2+ (above the resting level of approximately 100 nM). Brief activation of local AMPA receptors suppresses Ca2+ entry (probably by silencing 20-40 P/Q-type channels) in a subgroup of terminals that tend to show a higher dynamic range of Ca2+ signaling. The results provide the first quantitative description of presynaptic Ca2+ kinetics and its modulation by AMPA receptor activation (most likely via a glutamate spillover-mediated mechanism) at identified GABAergic synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.