Evidence map›Paper›PMID 15901505›Full record

ReviewCurrent opinion in cell biology2005

Dynamics of transcription and mRNA export.

Xavier Darzacq, Robert H Singer, Yaron Shav-Tal

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Visualizing nuclear RNAi activity in single living human cells.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Dynamic as well as stable protein interactions contribute to genome function and maintenance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011
    Article
  11. Article
  12. Article
  13. Article
  14. In vivo dynamics of RNA polymerase II transcription.Nature structural & molecular biology · 2007
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Xavier DarzacqDepartment of Anatomy, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Robert H Singer
Yaron Shav-Tal
Albert Einstein College of Medicine · US

Funding

LIGHT-ACTIVATED GENE EXPRESSION IN SINGLE CELLS(RMI)P20EB004930 · NIBIB · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI SINGER, ROBERT H · 2004 to 2008
$3.5M
SINGLE RNA MOLECULE MOVEMENT VISUALIZED IN LIVING CELLSR01EB002060 · NIBIB · YESHIVA UNIVERSITY · PI SINGER, ROBERT H · 2003 to 2008
$2.0M
NIBIB NIH HHS EB 2060NIBIB NIH HHS P20 EB004930NIBIB NIH HHS P20 EB4930NIBIB NIH HHS R01 EB002060
6 · The paper itself

Abstract

Understanding the different molecular mechanisms responsible for gene expression has been a central interest of molecular biologists for several decades. Transcription, the initial step of gene expression, consists of converting the genetic code into a dynamic messenger RNA that will specify a required cellular function following translocation to the cytoplasm and translation. We now possess an in-depth understanding of the mechanism and regulations of transcription. By contrast, an understanding of the dynamics of an individual gene's expression in real time is just beginning to emerge following recent technological developments.

Indexed as

Transcription, GeneticActive Transport, Cell NucleusAnimalsCell NucleusDNA-Directed RNA PolymerasesGene Expression RegulationHumansKineticsModels, GeneticRNA, MessengerRNA TransportTranscription FactorsTranscription Factors, TFIITranscription Factor TFIIHDNA-Directed RNA PolymerasesRNA, MessengerTranscription FactorsTranscription Factors, TFIITranscription Factor TFIIH

Identifiers

PMID15901505
PMCPMC4943869
OpenAlexW2161913443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.