ArticleThe Biochemical journal2005
A role for tumour necrosis factor alpha in human small bowel iron transport.
Article in The Biochemical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Microscopic enteritis: Bucharest consensus.World journal of gastroenterology · 2015Guideline
- Medium cut-off dialyzer improves erythropoiesis stimulating agent resistance in a hepcidin-independent manner in maintenance hemodialysis patients: results from a randomized controlled trial.Scientific reports · 2020Trial
- Iron status and dietary iron intake in relation to overweight/obesity in U.S. adults: a nationwide population-based study.Frontiers in nutrition · 2025Article
- Exploring the Causal Relationship Between Inflammatory Cytokines and MRI-Derived Brain Iron: A Mendelian Randomization Study.Brain and behavior · 2024Article
- Inflammatory markers in geriatric anemia: A study from North India.Journal of family medicine and primary care · 2023Article
- Fecal Iron Measurement in Studies of the Human Intestinal Microbiome.Current developments in nutrition · 2022Review
- Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study.Nutrients · 2021Article
- Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use.European heart journal · 2019Observational
- Iron and inflammation - the gut reaction.Metallomics : integrated biometal science · 2017Review
- Hepatic iron storage is related to body adiposity and hepatic inflammation.Nutrition & metabolism · 2017Article
- Clinical significance of C-reactive protein levels in predicting responsiveness to iron therapy in patients with inflammatory bowel disease and iron deficiency anemia.Digestive diseases and sciences · 2015Article
- Implications of malaria on iron deficiency control strategies.Advances in nutrition (Bethesda, Md.) · 2012Article
- Microscopic Enteritis; clinical features and correlations with symptoms.Gastroenterology and hepatology from bed to bench · 2012Article
- The hepcidin circuits act: balancing iron and inflammation.Hepatology (Baltimore, Md.) · 2011Article
- Cytokine regulation of OCTN2 expression and activity in small and large intestine.Inflammatory bowel diseases · 2011Article
- Intestinal ferroportin expression in pediatric Crohn's disease.Inflammatory bowel diseases · 2011Article
- Iron homeostasis and the inflammatory response.Annual review of nutrition · 2010Review
- Microscopic enteritis and pathomechanism of malabsorption.Auto- immunity highlights · 2010Review
- Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children.Blood · 2008Article
- Increased hepcidin expression in colorectal carcinogenesis.World journal of gastroenterology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Cytokines are integral to the development of anaemia of chronic inflammation. Cytokines modulate hepcidin expression and iron sequestration by the reticuloendothelial system but their direct effects on small bowel iron transport are not well characterized. The aim of the present study was to examine the local effects of TNFalpha (tumour necrosis factor alpha) on small bowel iron transport and on iron transporter expression in the absence of hepcidin. The effects of TNFalpha on iron transport were determined using radiolabelled iron in an established Caco-2 cell model. The effect of TNFalpha on the expression and localization of the enterocyte iron transporters DMT-1 (divalent metal transporter 1), IREG-1 (iron-regulated transporter 1) and ferritin was determined utilizing Caco-2 cells and in a human ex vivo small bowel culture system. TNFalpha mediated an early induction in both iron import and iron export, which were associated with increased DMT-1 and IREG-1 mRNA and protein expression (P<0.05). However, by 24 h, both iron import and iron export were significantly inhibited, coinciding with an induction of ferritin heavy chain (P<0.05) and a decrease in DMT-1 and IREG-1 to baseline levels. In addition, there was a relocalization of IREG-1 away from the basolateral cell border and increased iron deposition in villous enterocytes. In conclusion, TNFalpha has a direct effect on small bowel iron transporter expression and function, leading to an inhibition of iron transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.