ArticleImmunogenetics2005
Regulation of immunoglobulin gene transcription in a teleost fish: identification, expression and functional properties of E2A in the channel catfish.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Melanomacrophages and melanomacrophage centres inCentral-European journal of immunology · 2019Review
- Specific humoral immunity inCentral-European journal of immunology · 2018Review
- Transcription Factor T-Bet in Atlantic Salmon: Characterization and Gene Expression in Mucosal Tissues during Aeromonas Salmonicida Infection.Frontiers in immunology · 2015Article
- Perspectives on antigen presenting cells in zebrafish.Developmental and comparative immunology · 2014Review
- Dissecting teleost B cell differentiation using transcription factors.Developmental and comparative immunology · 2011Review
- The zebrafish IgH locus contains multiple transcriptional regulatory regions.Developmental and comparative immunology · 2011Article
- Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.Journal of cellular biochemistry · 2010Article
- BOB.1 of the channel catfish, Ictalurus punctatus: not a transcriptional coactivator?Molecular immunology · 2009Article
- Function of E-protein dimers expressed in catfish lymphocytes.Molecular immunology · 2008Article
- Interaction between E-protein and Oct transcription factors in the function of the catfish IGH enhancer.Developmental and comparative immunology · 2008Article
- Conservation and divergence of the Emicro3' enhancer in the IGH locus of teleosts.Immunogenetics · 2006Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The function of the transcriptional enhancer, Emu3', of the IgH locus of the channel catfish, Ictalurus punctatus, involves the interaction of E-protein and Oct family transcription factors. The E-proteins [class I basic helix-loop-helix (bHLH) family] are encoded in mammals by three genes: E2A (of which E12/E47 are alternatively spliced products), HEB, and E2-2. An E2A homologue has been identified in a catfish B-cell cDNA library and contains regions homologous to the bHLH and activation domains of mammalian and other vertebrate E2A proteins. E2A message is widely expressed, being readily detected in catfish B cells, T cells, kidney, spleen, brain, and muscle. Its expression is lower than that previously observed for TF12/CFEB, the catfish homologue of HEB. E2A strongly activated transcription of a muE5 motif-dependent construct in catfish B cells, and also activated transcription from the core region of the catfish IgH enhancer (Emu3') in a manner dependent on the presence of the muE5 site. Catfish E2A, expressed in vitro, bound the muE5 motif present in the core region of Emu3'. These results document the conservation of structure and function in vertebrate E2A and suggest a potential role of E2A in driving expression of the IgH locus at the phylogenetic level of a teleost fish.
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