Trial reportEuropean journal of clinical nutrition2005
Effects of soy supplementation on blood lipids and arterial function in hypercholesterolaemic subjects.
Trial report in European journal of clinical nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of whey and soy protein supplementation on inflammatory cytokines in older adults: a systematic review and meta-analysis.The British journal of nutrition · 2023Pooled it
- Effects of soy intake on circulating levels of TNF-α and interleukin-6: a systematic review and meta-analysis of randomized controlled trials.European journal of nutrition · 2021Pooled it
- Effects of plant protein and animal protein on lipid profile, body weight and body mass index on patients with hypercholesterolemia: a systematic review and meta-analysis.Acta diabetologica · 2020Pooled it
- Soy protein supplementation in men following radical prostatectomy: a 2-year randomized, placebo-controlled clinical trial.The American journal of clinical nutrition · 2021Trial
- Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT).Diabetologia · 2018Trial
- Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?Pharmaceuticals (Basel, Switzerland) · 2024Review
- The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.Inflammopharmacology · 2022Review
- Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile.Genes & nutrition · 2013Article
- Effect of dairy proteins on appetite, energy expenditure, body weight, and composition: a review of the evidence from controlled clinical trials.Advances in nutrition (Bethesda, Md.) · 2013Review
- Impact of postprandial glycaemia on health and prevention of disease.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2012Review
- A cross-over trial on soy intake and serum leptin levels in women with metabolic syndrome.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2010Article
- Equol: pharmacokinetics and biological actions.The Journal of nutrition · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies on soy supplementation suggest a cardioprotective potential.
objectiveTo examine the effects on LDL cholesterol and arterial function as a result of dietary enrichment with soy supplementation.
designA Randomized, double blind, parallel intervention trial.
settingDepartment of Endocrinology and Metabolism C, Aarhus University Hospital, and Department of Human Nutrition, The Royal Veterinary and Agricultural University, Denmark. SUBJECTS: In all, 100 hypercholesterolaemic but otherwise healthy subjects were included in the study of which 89 completed it.
interventionsSubjects were randomly assigned to 24 weeks of daily intake of either a soy supplement, Abalon (30 g soy protein, 9 g cotyledon fibre and 100 mg isoflavones) or placebo (30 g of casein). The soy supplement and placebo were provided in two sachets daily that were stirred in water. Fasting plasma lipids, TNF-alpha, homocysteine, insulin sensitivity, homeostasis model assessment (HOMA-IR), serum insulin, serum glucose, blood pressure as well as Glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic peptide (GIP) and plasma lipids to a fat-rich meal were recorded before and after the intervention. In a sub study in 32 subjects, arterial dilatory capacity, compliance, and distensibility were recorded before and after the intervention.
resultsIn the main study, no difference in fasting plasma lipid levels or insulin sensitivity was found between soy-based supplement and placebo. A significant postprandial increase in GIP to the meal test was observed in the soy group (P < 0.05). In a substudy, no difference between the groups in changes in flow-mediated vasodilatation (P = 0.84) was detected, while the soy supplementation caused a reduction in LDL and total cholesterol.
conclusionsNo significant effects on blood lipids were observed in the main study to a soy supplementation in hypercholesterolaemic subjects after 24 weeks. In the substudy, the soy supplementation, however, reduced LDL and total cholesterol but did not influence markers of arterial function.
Indexed as
Identifiers
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Registered trials
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