ArticleMolecular and cellular biology2005
Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Expression of Non-T Cell Activation Linker (NTAL) in Jurkat Cells Negatively Regulates TCR Signaling: Potential Role in Rheumatoid Arthritis.International journal of molecular sciences · 2023Article
- LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production.Journal of translational medicine · 2019Article
- Tetraspanins and Transmembrane Adaptor Proteins As Plasma Membrane Organizers-Mast Cell Case.Frontiers in cell and developmental biology · 2016Review
- Thymic negative selection is functional in NOD mice.The Journal of experimental medicine · 2012Article
- Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells.Frontiers in immunology · 2012Article
- Article
- A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity.Immunologic research · 2011Review
- LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?Journal of leukocyte biology · 2011Review
- Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes.Seminars in immunopathology · 2010Review
- Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.The Journal of biological chemistry · 2009Article
- Regulation of lymphocyte development and activation by the LAT family of adapter proteins.Immunological reviews · 2009Review
- Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.Journal of leukocyte biology · 2008Article
- Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells.The EMBO journal · 2007Article
- Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.Trends in immunology · 2007Review
- Ntal/Lab/Lat2.The international journal of biochemistry & cell biology · 2007Review
- Normal T-cell development and immune functions in TRIM-deficient mice.Molecular and cellular biology · 2006Article
- Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NTAL (non-T-cell activation linker, also called LAB) and LAT (linker for activation of T cells) are evolutionarily related transmembrane adaptor proteins that are phosphorylated upon immunoreceptor engagement. Using quantitative reverse transcription-PCR, both NTAL and LAT were found to be expressed in B cells. However, LAT expression was limited to early B cells, whereas NTAL expression typified mature B cells. To delineate their roles in B-cell development and function, Ntal-deficient mice were generated and crossed with Lat-deficient mice. B cells developed in Lat(-/-) Ntal(-/-) double-deficient mice and in mice lacking either of the two adaptors with the same efficiency as in wild-type mice. Upon B-cell antigen receptor cross-linking, Ntal(-/-) B cells exhibited slightly increased Ca(2+) mobilization and proliferation. In addition, Ntal-deficient mice had increased levels of natural antibodies and slightly increased humoral response to a T-dependent antigen. Normal titers of serum-specific immunoglobulins were produced in response to a T-cell-independent antigen. Although NTAL is also expressed in plasma cells, its absence did not affect the hypergammaglobulinemia E and G1 that developed in mice with a mutation in tyrosine 136 of LAT. Therefore, NTAL does not play a role in B cells symmetric to the role played by LAT in T cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.