ArticleArthritis research & therapy2005
Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis.
Article in Arthritis research & therapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 79 citations in OpenAlex.
- A Cross-Sectional Study on Elevated Serum Calcitonin Gene-Related Peptide Levels in Rheumatoid Arthritis Patients and Their Relationship with Disease Activity.Archives of rheumatology · 2026Article
- Bombesins: A New Frontier in Hybrid Compound Development.Pharmaceutics · 2023Review
- Capsaicin-Sensitive Peptidergic Sensory Nerves Are Anti-Inflammatory Gatekeepers in the Hyperacute Phase of a Mouse Rheumatoid Arthritis Model.International journal of molecular sciences · 2021Article
- Neurokinin receptors and their implications in various autoimmune diseases.Current research in immunology · 2021Review
- Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes.Frontiers in immunology · 2021Article
- Protein and gene markers of metabolic dysfunction and inflammation together associate with functional connectivity in reward and motor circuits in depression.Brain, behavior, and immunity · 2020Article
- What does plasma CRP tell us about peripheral and central inflammation in depression?Molecular psychiatry · 2020Article
- The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity.Frontiers in endocrinology · 2020Review
- Incidence of and Risk Factors for Complex Regional Pain Syndrome Type 1 after Surgery for Distal Radius Fractures: A Population-based Study.Scientific reports · 2019Article
- Heterogeneity of Human Mast Cells With Respect to MRGPRX2 Receptor Expression and Function.Frontiers in cellular neuroscience · 2019Article
- Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse.Journal of neuroinflammation · 2018Article
- Glucose and lipid-related biomarkers and the antidepressant response to infliximab in patients with treatment-resistant depression.Psychoneuroendocrinology · 2018Article
- Complex Role of Capsaicin-Sensitive Afferents in the Collagen Antibody-Induced Autoimmune Arthritis of the Mouse.Scientific reports · 2018Article
- Serum substance P: an indicator of disease activity and subclinical inflammation in rheumatoid arthritis.Clinical rheumatology · 2018Article
- Analgesic Microneedle Patch for Neuropathic Pain Therapy.ACS nano · 2017Article
- Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue.PloS one · 2015Article
- Protective Effect of Neuropeptide Substance P on Bone Marrow Mesenchymal Stem Cells against Apoptosis Induced by Serum Deprivation.Stem cells international · 2015Article
- Increasing substance P levels in serum and synovial tissues from patients with developmental dysplasia of the hip (DDH).BMC musculoskeletal disorders · 2014Article
- Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling.Molecular medicine (Cambridge, Mass.) · 2012Article
- Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that cytokines are highly involved in the disease process of rheumatoid arthritis (RA). Recently, targeting of neuropeptides has been suggested to have potential therapeutic effects in RA. The aim of this study was to investigate possible interrelations between five neuropeptides (bombesin/gastrin-releasing peptide (BN/GRP), substance P (SP), vasoactive intestinal peptide, calcitonin-gene-related peptide, and neuropeptide Y) and the three cytokines tumour necrosis factor (TNF)-alpha, IL-6, and monocyte chemoattractant protein-1 in synovial fluid of patients with RA. We also investigated possible interrelations between these neuropeptides and soluble TNF receptor 1 in serum from RA patients. Synovial fluid and sera were collected and assayed with ELISA or RIA. The most interesting findings were correlations between BN/GRP and SP and the cytokines. Thus, in synovial fluid, the concentrations of BN/GRP and SP grouped together with IL-6, and SP also grouped together with TNF-alpha and monocyte chemoattractant protein-1. BN/GRP and SP concentrations in synovial fluid also grouped together with the erythrocyte sedimentation rate. In the sera, BN/GRP concentrations and soluble TNF receptor 1 concentrations were correlated. These results are of interest because blocking of SP effects has long been discussed in relation to RA treatment and because BN/GRP is known to have trophic and growth-promoting effects and to play a role in inflammation and wound healing. Furthermore, the observations strengthen a suggestion that combination treatment with agents interfering with neuropeptides and cytokines would be efficacious in the treatment of RA. In conclusion, BN/GRP and SP are involved together with cytokines in the neuroimmunomodulation that occurs in the arthritic joint.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.