ReviewNeuroRx : the journal of the American Society for Experimental NeuroTherapeutics2005
Imaging of multiple sclerosis: role in neurotherapeutics.
Review in NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 109 citations in OpenAlex.
- Investigating the Ability of Radiomics Features for Diagnosis of the Active Plaque of Multiple Sclerosis Patients.Journal of biomedical physics & engineering · 2023Article
- Scan-Rescan Repeatability and Impact of BJournal of magnetic resonance imaging : JMRI · 2020Article
- TAPAS: A Thresholding Approach for Probability Map Automatic Segmentation in Multiple Sclerosis.NeuroImage. Clinical · 2020Article
- Magnetic Resonance Imaging in Multiple Sclerosis.Cold Spring Harbor perspectives in medicine · 2018Review
- A dual modeling approach to automatic segmentation of cerebral T2 hyperintensities and T1 black holes in multiple sclerosis.NeuroImage. Clinical · 2018Article
- A Clinical Approach to the Differential Diagnosis of Multiple Sclerosis.Current neurology and neuroscience reports · 2015Review
- Parallel changes in structural and functional measures of optic nerve myelination after optic neuritis.PloS one · 2015Article
- MP2RAGE provides new clinically-compatible correlates of mild cognitive deficits in relapsing-remitting multiple sclerosis.Journal of neurology · 2014Article
- The yearly rate of Relative Thalamic Atrophy (yrRTA): a simple 2D/3D method for estimating deep gray matter atrophy in Multiple Sclerosis.Frontiers in aging neuroscience · 2014Article
- Updates on clinically isolated syndrome and diagnostic criteria for multiple sclerosis.The Neurohospitalist · 2013Article
- Evaluation of [¹²³I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation.European journal of nuclear medicine and molecular imaging · 2011Article
- Superparamagnetic iron oxide nanoparticles: promises for diagnosis and treatment of multiple sclerosis.ACS chemical neuroscience · 2011Review
- MR imaging of inflammation during myelin-specific T cell-mediated autoimmune attack in the EAE mouse spinal cord.Molecular imaging and biology · 2010Article
- Characterization of white matter degeneration in elderly subjects by magnetic resonance diffusion and FLAIR imaging correlation.NeuroImage · 2009Article
- 3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis.NeuroImage · 2009Article
- MRI in multiple sclerosis: what's inside the toolbox?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2007Review
- Prediction of longitudinal brain atrophy in multiple sclerosis by gray matter magnetic resonance imaging T2 hypointensity.Archives of neurology · 2005Article
- Magnetic resonance imaging, microscopy, and spectroscopy of the central nervous system in experimental animals.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
- Foundations of advanced magnetic resonance imaging.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
- Single-photon emission computed tomography in neurotherapeutics.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Magnetic resonance imaging (MRI) plays an ever-expanding role in the evaluation of multiple sclerosis (MS). This includes its sensitivity for the diagnosis of the disease and its role in identifying patients at high risk for conversion to MS after a first presentation with selected clinically isolated syndromes. In addition, MRI is a key tool in providing primary therapeutic outcome measures for phase I/II trials and secondary outcome measures in phase III trials. The utility of MRI stems from its sensitivity to longitudinal changes including those in overt lesions and, with advanced MRI techniques, in areas affected by diffuse occult disease (the so-called normal-appearing brain tissue). However, all current MRI methodology suffers from limited specificity for the underlying histopathology. Conventional MRI techniques, including lesion detection and measurement of atrophy from T1- or T2-weighted images, have been the mainstay for monitoring disease activity in clinical trials, in which the use of gadolinium with T1-weighted images adds additional sensitivity and specificity for areas of acute inflammation. Advanced imaging methods including magnetization transfer, fluid attenuated inversion recovery, diffusion, magnetic resonance spectroscopy, functional MRI, and nuclear imaging techniques have added to our understanding of the pathogenesis of MS and may provide methods to monitor therapies more sensitively in the future. However, these advanced methods are limited by their cost, availability, complexity, and lack of validation. In this article, we review the role of conventional and advanced imaging techniques with an emphasis on neurotherapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.