ReviewNeuroRx : the journal of the American Society for Experimental NeuroTherapeutics2005
Single-photon emission computed tomography in neurotherapeutics.
Review in NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- SISCOS in focal cortical dysplasia: localization and comparative analysis with MRI.Neuroradiology · 2024Article
- Brain SPECT as a Biomarker of Neurodegeneration in Dementia in the Era of Molecular Imaging: Still a Valid Option?Frontiers in neurology · 2021Review
- Methods to measure, model and manipulate fluid flow in brain.Journal of neuroscience methods · 2020Review
- Imaging of cerebral blood flow in patients with severe traumatic brain injury in the neurointensive care.Frontiers in neurology · 2014Review
- Neuroimaging in epilepsy.Annals of Indian Academy of Neurology · 2011Article
- Molecular SPECT Imaging: An Overview.International journal of molecular imaging · 2011Article
- Magnetic resonance imaging, microscopy, and spectroscopy of the central nervous system in experimental animals.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
- Imaging of multiple sclerosis: role in neurotherapeutics.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
- Neuroimaging of epilepsy: therapeutic implications.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
- Neuroimaging and therapeutics in movement disorders.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
- Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer's disease.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
- Molecular optical imaging: applications leading to the development of present day therapeutics.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The measurement of regional cerebral blood flow (rCBF) by single-photon emission computed tomography (SPECT) is a powerful clinical and research tool. There are several clinical applications now documented, a substantial number under active investigation, and a larger number yet to be studied. Standards regarding patient imaging environment and image presentation are becoming established. This article reviews key aspects of SPECT functional brain imaging in clinical practice, with a particular emphasis on therapeutics, including 1) the quality of the tomographic device, 2) the radiopharmaceutical employed, 3) environmental conditions at the time of radiotracer administration, 4) characteristics of the subject, 5) the format used for image presentation, and 6) the essential components of image processing necessary to the achievement of high-quality SPECT brain images. Next, a brief description of relevant radiation safety issues is provided. Finally, applications in molecular imaging, especially in small animal imaging for research as well as drug discovery and development are discussed. The gamut of SPECT studies from currently routine clinical applications to molecular imaging offers a wonderful frontier for opportunities to employ functional brain imaging in neurotherapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.