ArticleOncogene2005
Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 74 citations in OpenAlex.
- Whence CRIPTO: The Reemergence of an Oncofetal Factor in 'Wounds' That Fail to Heal.International journal of molecular sciences · 2021Review
- Cripto-1 as a Key Factor in Tumor Progression, Epithelial to Mesenchymal Transition and Cancer Stem Cells.International journal of molecular sciences · 2021Review
- CRIPTO antagonist ALK4Breast cancer research : BCR · 2020Article
- Overexpression levels of cripto-1 predict poor prognosis in patients with prostate cancer following radical prostatectomy.Oncology letters · 2019Article
- Cripto-1 ablation disrupts alveolar development in the mouse mammary gland through a progesterone receptor-mediated pathway.The American journal of pathology · 2015Article
- Dynamic regulation of the cancer stem cell compartment by Cripto-1 in colorectal cancer.Cell death and differentiation · 2015Article
- Cripto-1 expression and its prognostic value in human bladder cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Genetic variants modulating CRIPTO serum levels identified by genome-wide association study in Cilento isolates.PLoS genetics · 2015Article
- The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition.Seminars in cancer biology · 2014Review
- Cripto haploinsufficiency affects in vivo colon tumor development.International journal of oncology · 2014Article
- Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors.Cellular signalling · 2013Article
- Pubertal high fat diet: effects on mammary cancer development.Breast cancer research : BCR · 2013Article
- Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis.FEBS letters · 2012Review
- Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.The American journal of pathology · 2012Review
- Differential mammary gland development in FVB and C57Bl/6 mice: implications for breast cancer research.Nutrients · 2011Article
- Expression and functional role of CRIPTO-1 in cutaneous melanoma.British journal of cancer · 2011Article
- Targeting the embryonic gene Cripto-1 in cancer and beyond.Expert opinion on therapeutic patents · 2010Review
- Role of Cripto-1 in stem cell maintenance and malignant progression.The American journal of pathology · 2010Review
- Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression.Journal of mammary gland biology and neoplasia · 2010Review
- Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions.World journal of gastroenterology · 2010Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
Human Cripto-1 (CR-1) is overexpressed in approximately 80% of human breast, colon and lung carcinomas. Mouse Cr-1 upregulation is also observed in a number of transgenic (Tg) mouse mammary tumors. To determine whether CR-1 can alter mammary gland development and/or may contribute to tumorigenesis in vivo, we have generated Tg mouse lines that express human CR-1 under the transcriptional control of the mouse mammary tumor virus (MMTV). Stable Tg MMTV/CR-1 FVB/N lines expressing different levels of CR-1 were analysed. Virgin female MMTV/CR-1 Tg mice exhibited enhanced ductal branching, dilated ducts, intraductal hyperplasia, hyperplastic alveolar nodules and condensation of the mammary stroma. Virgin aged MMTV/CR-1 Tg mice also possessed persistent end buds. In aged multiparous MMTV/CR-1 mice, the hyperplastic phenotype was most pronounced with multifocal hyperplasias. In the highest CR-1-expressing subline, G4, 38% (12/31) of the multiparous animals aged 12-20 months developed hyperplasias and approximately 33% (11/31) developed papillary adenocarcinomas. The long latency period suggests that additional genetic alterations are required to facilitate mammary tumor formation in conjunction with CR-1. This is the first in vivo study that shows hyperplasia and tumor growth in CR-1-overexpressing animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.