ArticleOncogene2005
Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Exploiting Translation Machinery for Cancer Therapy: Translation Factors as Promising Targets.International journal of molecular sciences · 2024Review
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- Mechanisms of miR-3189-3p-mediated inhibition of c-MYC translation in triple negative breast cancer.Cancer cell international · 2022Article
- Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes.Antiviral research · 2018Article
- Translation Control byCancers · 2018Article
- Article
- Article
- The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E (eIF4E) and inhibits protein synthesis in MG63 osteosarcoma cells.Genes & diseases · 2016Article
- PC-1/PrLZ confers resistance to rapamycin in prostate cancer cells through increased 4E-BP1 stability.Oncotarget · 2015Article
- mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions.Molecular biology international · 2014Review
- Anti-oncogenic potential of the eIF4E-binding proteins.Oncogene · 2013Review
- Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes.The Journal of biological chemistry · 2011Article
- Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.PloS one · 2011Article
- Article
- The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.Aging · 2010Article
- Paradoxical suppression of cellular senescence by p53.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Regulation of protein synthesis by ionizing radiation.Molecular and cellular biology · 2009Article
- Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway.Circulation · 2009Article
- Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1.Oncogene · 2008Article
- mTOR signalling in human cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2007Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of a temperature-sensitive form of mouse p53 in murine erythroleukaemia cells rapidly inhibits protein synthesis and causes early dephosphorylation and cleavage of protein synthesis initiation factor eIF4GI and the eIF4E-binding protein 4E-BP1. Dephosphorylated 4E-BP1 and the cleaved products of 4E-BP1 and eIF4GI associate with eIF4E under these conditions, concomitant with decreased interaction of full-length eIF4GI with eIF4E. These changes may play an important role in preventing formation of the eIF4F complex and thus the initiation of protein synthesis. As observed previously for eIF4GI, the cleavage of 4E-BP1 is insensitive to the general caspase inhibitor z-VAD.FMK, consistent with a caspase-independent mechanism of factor modification and regulation of protein synthesis. Comparison of the p53-induced patterns of eIF4GI and 4E-BP1 dephosphorylation and cleavage with those caused by the mTOR inhibitor rapamycin indicates that p53 activation and rapamycin have distinct but additive effects. Moreover, p53 activation inhibits rapamycin-insensitive protein kinase activity against 4E-BP1. P53 and rapamycin have additive effects on the inhibition of overall protein synthesis. These data suggest that the inhibition of protein synthesis by p53 is largely independent of the regulation of rapamycin-sensitive mTOR in the system under investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.