ArticleOncogene2005
Array-based comparative gene expression analysis of tumor cells with increased apoptosis resistance after hypoxic selection.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia.Frontiers in oncology · 2018Article
- CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity.Cell metabolism · 2017Article
- Preservation of high glycolytic phenotype by establishing new acute lymphoblastic leukemia cell lines at physiologic oxygen concentration.Experimental cell research · 2015Article
- Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.PLoS genetics · 2015Article
- Human activated macrophages and hypoxia: a comprehensive review of the literature.Iranian journal of basic medical sciences · 2014Article
- TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells.BMC cancer · 2012Article
- Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation.Oncotarget · 2011Article
- In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.Cancer research · 2011Article
- BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells.Neoplasia (New York, N.Y.) · 2008Article
- Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.PLoS medicine · 2006Article
- Gene expression profile of B 16(F10) murine melanoma cells exposed to hypoxic conditions in vitro.Gene expression · 2006Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor hypoxia is an adverse prognostic factor. In a recent study, we could demonstrate that cyclic hypoxia selects for hypoxia-tolerant tumor cells, which are cross-resistant to other stimuli of mitochondrial death pathways. In contrast, sensitivity of the cells to death-receptor ligands was mainly not affected. The aim of the present study was to further elucidate cellular changes induced by cyclic hypoxia and to identify alterations in gene expression pattern upon hypoxic selection by means of DNA-microarray analysis. Our data reveal that cyclic hypoxia resulted in the selection of cells with resistance to doxorubicine and radiation. Furthermore, hypoxic selection was accompanied by constitutive changes of the gene expression pattern with downregulation of 156 and upregulation of 82 genes. Most of the differentially regulated genes were involved in cellular responses to hypoxia and reoxygenation. While many of the genes that were downregulated upon hypoxic selection represent genes that are usually upregulated by acute hypoxia, the genes that were upregulated represent genes that are involved in stress resistance and anti-apoptotic signalling. Most importantly, hypoxic selection was not associated with changes of single apoptosis relevant genes, but with alterations in gene expression levels of a wide variety of genes indicating a more complex adaptation process.
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Registered trials
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