ReviewJournal of industrial microbiology & biotechnology2005
Genomic insights into the iron uptake mechanisms of the biomining microorganism Acidithiobacillus ferrooxidans.
Review in Journal of industrial microbiology & biotechnology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Novel metal sites revealed by spectroscopic and structural characterization of the ferric uptake regulator fromComputational and structural biotechnology journal · 2025Article
- Transcriptome Analysis of Cyclooctasulfur Oxidation and Reduction by the Neutrophilic ChemolithoautotrophicAntioxidants (Basel, Switzerland) · 2023Article
- Potential and whole-genome sequence-based mechanism of elongated-prismatic magnetite magnetosome formation in Acidithiobacillus ferrooxidans BYM.World journal of microbiology & biotechnology · 2022Article
- Ferric Uptake Regulator Provides a New Strategy for Acidophile Adaptation to Acidic Ecosystems.Applied and environmental microbiology · 2020Article
- Complete Genome Sequence ofMicroorganisms · 2019Article
- The Type IV Secretion System of ICEFrontiers in microbiology · 2019Article
- Integration of Biological Networks forFrontiers in molecular biosciences · 2019Article
- Acidithiobacillus ferrooxidans and its potential application.Extremophiles : life under extreme conditions · 2018Review
- Insights into the fluoride-resistant regulation mechanism of Acidithiobacillus ferrooxidans ATCC 23270 based on whole genome microarrays.Journal of industrial microbiology & biotechnology · 2016Article
- Microbial Surface Colonization and Biofilm Development in Marine Environments.Microbiology and molecular biology reviews : MMBR · 2016Review
- Draft genome sequence of extremely acidophilic bacterium Acidithiobacillus ferrooxidans DLC-5 isolated from acid mine drainage in Northeast China.Genomics data · 2015Article
- Microbial diversity and metabolic networks in acid mine drainage habitats.Frontiers in microbiology · 2015Review
- Energy, ecology and the distribution of microbial life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications.BMC genomics · 2008Article
- Microbial iron management mechanisms in extremely acidic environments: comparative genomics evidence for diversity and versatility.BMC microbiology · 2008Article
- Periplasmic proteins of the extremophile Acidithiobacillus ferrooxidans: a high throughput proteomics analysis.Molecular & cellular proteomics : MCP · 2007Article
- Analysis of a ferric uptake regulator (Fur) mutant of Desulfovibrio vulgaris Hildenborough.Applied and environmental microbiology · 2007Article
- Bioinformatic prediction and experimental verification of Fur-regulated genes in the extreme acidophile Acidithiobacillus ferrooxidans.Nucleic acids research · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Commercial bioleaching of copper and the biooxidation of gold is a cost-effective and environmentally friendly process for metal recovery. A partial genome sequence of the acidophilic, bioleaching bacterium Acidithiobacillus ferrooxidans is available from two public sources. This information has been used to build preliminary models that describe how this microorganism confronts unusually high iron loads in the extremely acidic conditions (pH 2) found in natural environments and in bioleaching operations. A. ferrooxidans contains candidate genes for iron uptake, sensing, storage, and regulation of iron homeostasis. Predicted proteins exhibit significant amino acid similarity with known proteins from neutrophilic organisms, including conservation of functional motifs, permitting their identification by bioinformatics tools and allowing the recognition of common themes in iron transport across distantly related species. However, significant differences in amino acid sequence were detected in pertinent domains that suggest ways in which the periplasmic and outer membrane proteins of A. ferrooxidans maintain structural integrity and relevant protein-protein contacts at low pH. Unexpectedly, the microorganism also contains candidate genes, organized in operon-like structures that potentially encode at least 11 siderophore systems for the uptake of Fe(III), although it does not exhibit genes that could encode the biosynthesis of the siderophores themselves. The presence of multiple Fe(III) uptake systems suggests that A. ferrooxidans can inhabit aerobic environments where iron is scarce and where siderophore producers are present. It may also help to explain why it cannot tolerate high Fe(III) concentrations in bioleaching operations where it is out-competed by Leptospirillum species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.