Evidence map›Paper›PMID 15895191›Full record

ArticleImmunogenetics2005

The design and implementation of the immune epitope database and analysis resource.

Bjoern Peters, John Sidney, Phil Bourne, Huynh-Hoa Bui, Soeren Buus, Grace Doh, Ward Fleri, Mitch Kronenberg, Ralph Kubo, Ole Lund and 9 more

Open access · greenAbstract read
In one paragraph

Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 115 citations in OpenAlex.

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  10. Frontiers in immunology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Bjoern PetersLa Jolla Institute of Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA.
John Sidney
Phil Bourne
Huynh-Hoa Bui
Soeren Buus
Grace Doh
Ward Fleri
Mitch Kronenberg
Ralph Kubo
Ole Lund
David Nemazee
Julia V Ponomarenko
Muthu Sathiamurthy
Stephen P Schoenberger
Scott Stewart
Pamela Surko
Scott Way
Steve Wilson
Alessandro Sette
La Jolla Institute for Immunology · USScience Applications International Corporation (United States) · USSan Diego Supercomputer Center · USGrace (United States) · USScripps Research Institute · USTechnical University of Denmark · DKUniversity of Copenhagen · DK

Funding

Immune Tolerance in Non-Clonal Immune SystemsR01AI059714 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMAZEE, DAVID · 2004 to 2013
$3.9M
NIAID NIH HHS HHSH266200400006CNIAID NIH HHS R01 AI059714
6 · The paper itself

Abstract

Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and fight diseases. Their scientific importance is reflected in the vast amount of epitope-related information gathered, ranging from interactions between epitopes and major histocompatibility complex molecules determined by X-ray crystallography to clinical studies analyzing correlates of protection for epitope based vaccines. Our goal is to provide a central resource capable of capturing this information, allowing users to access and connect realms of knowledge that are currently separated and difficult to access. Here, we portray a new initiative, "The Immune Epitope Database and Analysis Resource." We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide.

Indexed as

Databases, FactualEpitopesAnimalsHumansImmunodominant EpitopesInternetProtein Structure, TertiaryEpitopesImmunodominant Epitopes

Identifiers

PMID15895191
PMCPMC4780685
OpenAlexW2048848017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.