Xanthine oxidase inhibition for chronic heart failure: is allopurinol the next therapeutic advance in heart failure?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. High serum uric acid levels may increase mortality and major adverse cardiovascular events in patients with acute myocardial infarction.Saudi medical journal · 2017
   Pooled it
2. A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: A pilot study.PloS one · 2017
   Trial
3. The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial.British journal of clinical pharmacology · 2009
   Trial
4. The Effect of High-dose Allopurinol Pretreatment on Inflammatory Biomarkers and Post-revascularization Coronary Blood Flow in Non-STEMI Patients: A Randomized Double Blind Clinical Trial.ARYA atherosclerosis · 2023
   Article
5. The cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients.Scientific reports · 2021
   Article
6. Associations of serum uric acid level and gout with cardiac structure, function and sex differences from large scale asymptomatic Asians.PloS one · 2020
   Article
7. Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout.PloS one · 2020
   Article
8. Left ventricular ejection fraction as therapeutic target: is it the ideal marker?Heart failure reviews · 2017
   Review
9. CVD and Oxidative Stress.Journal of clinical medicine · 2017
   Review
10. Uric acid: where are we?Journal of clinical hypertension (Greenwich, Conn.) · 2013
    Article
11. Effects of Greek legume plant extracts on xanthine oxidase, catalase and superoxide dismutase activities.Journal of physiology and biochemistry · 2012
    Article
12. Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension?Medical hypotheses · 2010
    Article
13. Lipid peroxidation and antioxidant enzyme activities in cancerous bladder tissue and their relation with bacterial infection: a controlled clinical study.Journal of clinical laboratory analysis · 2010
    Article
14. Biomarkers for chronic heart failure : diagnostic, prognostic, and therapeutic challenges.Herz · 2009
    Review
15. Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis.Arthritis research & therapy · 2009
    Article
16. Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?European journal of nutrition · 2007
    Review
17. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol.Pharmacological reviews · 2006
    Review
18. Glutamate synthase: a fascinating pathway from L-glutamine to L-glutamate.Cellular and molecular life sciences : CMLS · 2004
    Review

Corrections and comments

• Comment on
  Allopurinol reduces B-type natriuretic peptide concentrations and haemoglobin but does not alter exercise capacity in chronic heart failure.2005

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as