ArticleProceedings of the National Academy of Sciences of the United States of America2005
Sexually dimorphic expression of trkB, a Z-linked gene, in early posthatch zebra finch brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 69 citations in OpenAlex.
- Molecular insights into region-specific sexual dichromatism: Comparative transcriptome analysis of red cheek pigmentation in zebra finches.PLoS genetics · 2025Article
- Article
- Single-molecule long-read sequencing reveals the potential impact of posttranscriptional regulation on gene dosage effects on the avian Z chromosome.BMC genomics · 2022Article
- Profile of gene expression changes during estrodiol-17β-induced feminization in the Takifugu rubripes brain.BMC genomics · 2021Article
- DNA Methylation Regulates Transcription Factor-Specific Neurodevelopmental but Not Sexually Dimorphic Gene Expression Dynamics in Zebra Finch Telencephalon.Frontiers in cell and developmental biology · 2021Article
- Transcriptomic analyses reveal novel genes with sexually dimorphic expression in Takifugu rubripes brain during gonadal sex differentiation.Genes & genomics · 2020Article
- Urotensin-related gene transcripts mark developmental emergence of the male forebrain vocal control system in songbirds.Scientific reports · 2019Article
- Inhibition of TrkB limits development of the zebra finch song system.Brain research · 2016Article
- Genetic regulation of sex differences in songbirds and lizards.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Dynamic gene expression in the song system of zebra finches during the song learning period.Developmental neurobiology · 2015Article
- Transcriptomic Analyses Reveal Novel Genes with Sexually Dimorphic Expression in Yellow Catfish (Pelteobagrus fulvidraco) Brain.Marine biotechnology (New York, N.Y.) · 2015Article
- Masculinisation of the zebra finch song system: roles of oestradiol and the Z-chromosome gene tubulin-specific chaperone protein A.Journal of neuroendocrinology · 2015Article
- Article
- Testosterone and brain-derived neurotrophic factor interactions in the avian song control system.Neuroscience · 2013Review
- Cell-autonomous sex determination outside of the gonad.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Review
- 17β-estradiol regulates the sexually dimorphic expression of BDNF and TrkB proteins in the song system of juvenile zebra finches.PloS one · 2012Article
- Article
- The effects of estradiol on 17β-hydroxysteroid dehydrogenase type IV and androgen receptor expression in the developing zebra finch song system.Brain research · 2011Article
- Injury-induced regulation of steroidogenic gene expression in the cerebellum.Journal of neurotrauma · 2010Article
- Neural expression and post-transcriptional dosage compensation of the steroid metabolic enzyme 17beta-HSD type 4.BMC neuroscience · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sexual differentiation of the zebra finch (Taeniopygia guttata) neural song circuit is thought to be initiated by sex differences in sex chromosome gene expression in brain cells. One theory is that Z-linked genes, present in the male's ZZ genome at double the dose of females' (ZW), are expressed at higher levels and trigger masculine patterns of development. We report here that trkB (tyrosine kinase receptor B) is Z-linked in zebra finches. trkB is the receptor for neurotrophic factors BDNF and neurotrophin 4, and mediates their influence on neuronal survival, migration, and specification. trkB mRNA is expressed at a higher level in the male telencephalon or whole brain than in corresponding regions of the female in adulthood, and at posthatch day (P) 6, when the song circuit is undergoing sexual differentiation. Moreover, this expression is higher in the song nucleus high vocal center (HVC) than in the surrounding telencephalon at P6, and in males relative to females. In addition, trkB protein is expressed more highly in male than female whole brain at P6. These results establish trkB as a candidate factor that contributes to masculine differentiation of HVC because of its Z-linkage, which leads to sex differences in expression. BDNF is known to be stimulated by estrogen and to be expressed at higher levels in males than females at later ages in HVC. Thus, the trkB-BDNF system may be a focal point for convergent masculinizing influences of Z-linked factors and hormones.
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