ArticleProceedings of the National Academy of Sciences of the United States of America2005
Subsecond reorganization of the actin network in cell motility and chemotaxis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 113 citations in OpenAlex.
- Review
- Non-Transport Functions of Aquaporins.Advances in experimental medicine and biology · 2023Article
- Actin dynamics in protein homeostasis.Bioscience reports · 2022Review
- Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation.Theranostics · 2022Article
- Formins specify membrane patterns generated by propagating actin waves.Molecular biology of the cell · 2020Article
- Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling.PLoS computational biology · 2019Article
- Motility Control of Symbionts and Organelles by the Eukaryotic Cell: The Handling of the Motile Capacity of Individual Parts Forges a Collective Biological Identity.Frontiers in psychology · 2019Article
- Miniature scanning light-sheet illumination implemented in a conventional microscope.Biomedical optics express · 2018Article
- Mechanisms of Aquaporin-Facilitated Cancer Invasion and Metastasis.Frontiers in chemistry · 2018Review
- Super-Resolution Microscopy: Shedding Light on the Cellular Plasma Membrane.Chemical reviews · 2017Review
- Self-organizing actin patterns shape membrane architecture but not cell mechanics.Nature communications · 2017Article
- Theoretical study of actin layers attachment and separation.The European physical journal. E, Soft matter · 2015Article
- Computational model of polarized actin cables and cytokinetic actin ring formation in budding yeast.Cytoskeleton (Hoboken, N.J.) · 2015Article
- Image based validation of dynamical models for cell reorientation.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2015Article
- Scanning x-ray nanodiffraction on Dictyostelium discoideum.Biophysical journal · 2014Article
- Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution.Science (New York, N.Y.) · 2014Article
- The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases.Cellular and molecular life sciences : CMLS · 2014Article
- Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- PIP3 waves and PTEN dynamics in the emergence of cell polarity.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Actin networks are continuously reorganized in cells that rapidly change their shape. Applying total internal reflection fluorescence microscopy at acquisition rates of 10-20 Hz, we measured an average growth rate of 3 microm.sec(-1) for filamentous actin structures throughout the entire substrate-attached cortex of Dictyostelium cells. New filaments often proceed along preexisting ones, resulting in bundle formation concurrent with filament growth. In cells that orientate in a gradient of chemoattractant, prominent assemblies of actin enriched in the Arp2/3 complex are inserted into the network, primarily at the base of filopods that point into the direction of the gradient. We propose that high turnover rates of actin filaments confer the plasticity to the cell cortex that is required for rapid accommodation to external stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.