ArticleImmunology letters2005
Intestinal TSH production is localized in crypt enterocytes and in villus 'hotblocks' and is coupled to IL-7 production: evidence for involvement of TSH during acute enteric virus infection.
Article in Immunology letters, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Local TSH/TSHR signaling promotes CD8Cancer communications (London, England) · 2024Article
- Dynamic Interactions Between the Immune System and the Neuroendocrine System in Health and Disease.Frontiers in endocrinology · 2021Review
- Novel Splicing of Immune System Thyroid Stimulating Hormone β-Subunit-Genetic Regulation and Biological Importance.Frontiers in endocrinology · 2019Review
- Biological Impact of the TSHβ Splice Variant in Health and Disease.Frontiers in immunology · 2014Review
- Newborn screening for autism: in search of candidate biomarkers.Biomarkers in medicine · 2013Article
- Review
- Immunological regulation of metabolism--a novel quintessential role for the immune system in health and disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- The role of NK cells in the autoimmune thyroid disease-associated pregnancy loss.Clinical reviews in allergy & immunology · 2010Review
- Virus infection activates thyroid stimulating hormone synthesis in intestinal epithelial cells.Journal of cellular biochemistry · 2008Article
- The immune system as a regulator of thyroid hormone activity.Experimental biology and medicine (Maywood, N.J.) · 2006Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The immune and neuroendocrine systems have been shown to work conjointly in a number of ways. One aspect of this has to do with a potential role for thyroid stimulating hormone (TSH) in the regulation of the mucosal immune system, although the mechanisms by which this occurs remain vague. To more thoroughly understand how TSH participates in intestinal intraepithelial lymphocyte (IEL) development and immunity, experiments have been conducted to define local sites of intestinal TSH production, and to characterize changes that occur in the synthesis of TSH during acute enteric virus infection. Here, we demonstrate that TSH in the small intestine is specifically localized to regions below villus crypts as seen by immunocytochemical staining, which revealed high-level TSH staining in lower crypts in the absence of IL-7 staining, and TSH and IL-7 co-staining in upper crypt regions. Additionally, prominent TSH staining was evident in TSH 'hotblocks' sparsely dispersed throughout the epithelial layer. In rotavirus-infected mice, the TSH staining pattern differed significantly from that of non-infected animals. Notably, at 2 and 3 days post-infection, TSH expression was high in and near apical villi where virus infection was greatest. These findings lend credence to the notion that TSH plays a role both in the development of intestinal T cells, and in the process of local immunity during enteric virus infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.