ArticleGene expression2005
Exercise-induced gene expression changes in the rat spinal cord.
Article in Gene expression, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Brief early-life motor training induces behavioral changes and alters neuromuscular development in mice.PLoS biology · 2025Article
- Dose-dependent effects of testosterone on proteins related to nitric oxide signaling pathway and trophic factors in the spinal cord of adolescent trained rats.Frontiers in sports and active living · 2025Article
- Differential effects of exercise and hormone treatment on spinal cord injury-induced changes in micturition and morphology of external urethral sphincter motoneurons.Restorative neurology and neuroscience · 2024Article
- Article
- Combined Supra- and Sub-Lesional Epidural Electrical Stimulation for Restoration of the Motor Functions after Spinal Cord Injury in Mini Pigs.Brain sciences · 2020Article
- Downstream Consequences of Exercise Through the Action of BDNF.Brain plasticity (Amsterdam, Netherlands) · 2015Article
- Female Rats Demonstrate Improved Locomotor Recovery and Greater Preservation of White and Gray Matter after Traumatic Spinal Cord Injury Compared to Males.Journal of neurotrauma · 2015Article
- Role of exercise in maintaining the integrity of the neuromuscular junction.Muscle & nerve · 2014Review
- Differential cortical neurotrophin and cytogenetic adaptation after voluntary exercise in normal and amnestic rats.Neuroscience · 2014Article
- Functional electrical stimulation in spinal cord injury:: from theory to practice.Topics in spinal cord injury rehabilitation · 2012Article
- Neurotrophin-4/5 is implicated in the enhancement of axon regeneration produced by treadmill training following peripheral nerve injury.The European journal of neuroscience · 2011Article
- Voluntary exercise increases oligodendrogenesis in spinal cord.The International journal of neuroscience · 2010Article
- Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males.PloS one · 2008Article
- Exercise and brain health--implications for multiple sclerosis: Part 1--neuronal growth factors.Sports medicine (Auckland, N.Z.) · 2008Review
- Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender.Genome biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
There is growing evidence that exercise benefits recovery of neuromuscular function from spinal cord injury (SCI). However, the effect of exercise on gene expression in the spinal cord is poorly understood. We used oligonucleotide microarrays to compare thoracic and lumbar regions of spinal cord of either exercising (voluntary wheel running for 21 days) or sedentary rats. The expression data were filtered using statistical tests for significance, and K-means clustering was then used to segregate lists of significantly changed genes into sets based upon expression patterns across all experimental groups. Levels of brain-derived neurotrophic factor (BDNF) protein were also measured after voluntary exercise, across different regions of the spinal cord. BDNF mRNA increased with voluntary exercise, as has been previously shown for other forms of exercise, contributed to by increases in both exon I and exon III. The exercise-induced gene expression changes identified by microarray analysis are consistent with increases in pathways promoting neuronal health, signaling, remodeling, cellular transport, and development of oligodendrocytes. Taken together these data suggest cellular pathways through which exercise may promote recovery in the SCI population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.