ArticleMolecular reproduction and development2005
DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis.
Article in Molecular reproduction and development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function.Cell & bioscience · 2026Article
- Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study.Clinical proteomics · 2025Article
- Whole-Genome Identification and Characterization of the DKK Gene Family and Its Transcription Profiles: An Analysis of the Chinese Soft-Shell Turtle (Animals : an open access journal from MDPI · 2024Article
- Article
- Dkk3/REIC Deficiency Impairs Spermiation, Sperm Fibrous Sheath Integrity and the Sperm Motility of Mice.Genes · 2022Article
- Identification of an immunogenic DKK1 long peptide for immunotherapy of human multiple myeloma.Haematologica · 2021Article
- [Expression of DKKL1 in spermatozoa of men with asthenospermia].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics.Scientific reports · 2017Article
- CKAP4 is identified as a receptor for Dickkopf in cancer cells.The Journal of clinical investigation · 2016Article
- Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models.Cell death & disease · 2016Article
- Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes.The Journal of endocrinology · 2014Article
- Secreted and transmembrane wnt inhibitors and activators.Cold Spring Harbor perspectives in biology · 2013Review
- Developmental expression and function of DKKL1/Dkkl1 in humans and mice.Reproductive biology and endocrinology : RB&E · 2012Article
- Article
- SLXL1, a novel acrosomal protein, interacts with DKKL1 and is involved in fertilization in mice.PloS one · 2011Article
- Identification of fucosylated glycoconjugates in Xenopus laevis testis by lectin histochemistry.Histochemistry and cell biology · 2010Article
- The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility.Fertility and sterility · 2010Article
- Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis.Biology of reproduction · 2010Article
- The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein.Biology of reproduction · 2009Article
- A Wnt survival guide: from flies to human disease.The Journal of investigative dermatology · 2009Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Dickkopf-like 1 (DkkL1) is related to the Dickkopf gene family, a group of proteins that are characterized as secreted antagonists of Wingless (Wnt) signal transduction proteins. DkkL1 mRNA is found in preimplantation mouse embryos and in developing neural tissue, but in adults it is found primarily in the testes. In an effort to elucidate its function, the distribution of DkkL1 protein in mouse testis and mature sperm was analyzed by immuno-histochemistry and immuno-blotting techniques. DkkL1 first appeared in the developing spermatocytes in seminiferous tubules as early as Stage XII, coincident with the appearance of DkkL1 mRNA. Surprisingly, however, DkkL1 localized to the developing acrosome in spermatocytes and spermatids and to the acrosome in mature sperm. Furthermore, DkkL1 was N-glycosylated in the testis, but it did not appear to be excreted, and the DkkL1 in mature sperm was no longer N-glycosylated, suggesting that additional post-translational modifications occurred during the final stages of spermatogenesis. These results identify a member of the Dickkopf family as a novel acrosomal protein that may be involved in acrosome assembly or function, a unique role for a secreted signaling molecule.
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