ArticleHistochemistry and cell biology2005
Microsomal triglyceride transfer protein expression in mouse intestine.
Article in Histochemistry and cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Gene transfer and genome editing for familial hypercholesterolemia.Frontiers in molecular medicine · 2023Review
- FoxO integration of insulin signaling with glucose and lipid metabolism.The Journal of endocrinology · 2017Review
- The Lipid-lowering Effects and Associated Mechanisms of Dietary Phytosterol Supplementation.Current pharmaceutical design · 2017Review
- Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes.Biochimica et biophysica acta · 2016Review
- Insights from human congenital disorders of intestinal lipid metabolism.Journal of lipid research · 2015Review
- On the function and homeostasis of PCSK9: reciprocal interaction with LDLR and additional lipid effects.Atherosclerosis · 2015Review
- Article
- Article
- Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine.Journal of lipid research · 2012Article
- Mechanism of hypertriglyceridemia in CTP:phosphoethanolamine cytidylyltransferase-deficient mice.Journal of lipid research · 2012Article
- Role of the gut in lipid homeostasis.Physiological reviews · 2012Review
- Multiple functions of microsomal triglyceride transfer protein.Nutrition & metabolism · 2012Article
- Intestinal mucosal triacylglycerol accumulation secondary to decreased lipid secretion in obese and high fat fed mice.Frontiers in physiology · 2012Article
- NR2F1 and IRE1beta suppress microsomal triglyceride transfer protein expression and lipoprotein assembly in undifferentiated intestinal epithelial cells.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- FoxO1 integrates insulin signaling to VLDL production.Cell cycle (Georgetown, Tex.) · 2008Review
- FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice.The Journal of clinical investigation · 2008Article
- The histochemistry and cell biology vade mecum: a review of 2005-2006.Histochemistry and cell biology · 2006Review
- Recent progress in histochemistry and cell biology: the state of the art 2005.Histochemistry and cell biology · 2005Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Immunohistochemical and biochemical approaches were utilized to compare the expression of microsomal triglyceride transfer protein (MTP) and cellular retinol binding protein II (CRBPII) with the expression of apolipoprotein (apo)B and apoA-I along the entire length of the small intestine in mice. MTP is expressed in villus-associated enterocytes along the length of the small intestine. Maximal expression occurs within the first 20% of the intestine and decreases to less than 3% of maximum in the distal third of the intestine. The expression of CRBPII is nearly identical with that of MTP. Peak expression of apoB and apoA-I occurs in the first 25% of the intestine; however, expression in the most distal segments of the intestine is 10%-15% of maximum expression. In mice fed a Western diet for 3 weeks the expression of MTP and CRBPII was elevated in the distal regions of the intestine, whereas the expression patterns for apoB and apoA-I were similar to those found in mice on control diets. We conclude that the patterns of expression, as well as the regulation of MTP and CRBPII, are similar. However, the expression and regulation of these two proteins differ from those of apoB and apoA-I. In particular, the expression of MTP is not coordinated with the expression of apoB, even though the two proteins are essential for the assembly and secretion of chylomicrons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.