ReviewThe Journal of physiology2005
NaPi-IIa and interacting partners.
Review in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- The Intricacies of Renal Phosphate Reabsorption-An Overview.International journal of molecular sciences · 2024Review
- Article
- Mechanisms of phosphate transport.Nature reviews. Nephrology · 2019Review
- Visualizing the regulation of SLC34 proteins at the apical membrane.Pflugers Archiv : European journal of physiology · 2019Review
- PTH and Vitamin D.Comprehensive Physiology · 2016Review
- Identification of an RNA-binding protein that is phosphorylated by PTH and potentially mediates PTH-induced destabilization of Npt2a mRNA.American journal of physiology. Cell physiology · 2016Article
- The endocytic receptor megalin and its associated proteins in proximal tubule epithelial cells.Membranes · 2014Article
- Renal phosphate handling: Physiology.Indian journal of endocrinology and metabolism · 2013Article
- Article
- Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.The Journal of biological chemistry · 2012Article
- Genetic disorders of phosphate regulation.Pediatric nephrology (Berlin, Germany) · 2012Review
- Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transport.The Journal of biological chemistry · 2012Article
- Role of PDZK1 protein in apical membrane expression of renal sodium-coupled phosphate transporters.The Journal of biological chemistry · 2011Article
- Lifestyle diseases and cardiovascular risk factors are interrelated to deficiencies of major substrates in ATP synthesis.Vascular health and risk management · 2010Article
- Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney.The Journal of biological chemistry · 2010Article
- CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.American journal of physiology. Renal physiology · 2010Article
- PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP.American journal of physiology. Renal physiology · 2009Article
- NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.The Journal of biological chemistry · 2009Article
- Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.The Journal of clinical investigation · 2009Article
- Discovery of alpha-Klotho unveiled new insights into calcium and phosphate homeostasis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Regulation of renal proximal tubular reabsorption of phosphate (Pi) is one of the critical steps in Pi homeostasis. Experimental evidence suggests that this regulation is achieved mainly by controlling the apical expression of the Na+-dependent Pi cotransporter type IIa (NaPi-IIa) in proximal tubules. Only recently have we started to obtain information regarding the molecular mechanisms that control the apical expression of NaPi-IIa. The first critical observation was the finding that truncation of only its last three amino acid residues has a strong effect on apical expression. A second major finding was the observation that the last intracellular loop of NaPi-IIa contains sequence information that confers parathyroid hormone (PTH) sensitivity. The use of the above domains of the cotransporter in yeast two-hybrid (Y2H) screening allowed the identification of proteins interacting with NaPi-IIa. Biochemical and morphological, as well as functional, analyses have allowed us to obtain insights into the physiological roles of such interactions, although our present knowledge is still far from complete.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.