ArticleMolecular and cellular biology1992
Functional dissection of the lck proximal promoter.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 115 citations in OpenAlex.
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- E-Protein Inhibition in ILC2 Development Shapes the Function of Mature ILC2s during Allergic Airway Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun.Scientific reports · 2017Article
- T-cell development is regulated by the coordinated function of proximal and distal Lck promoters active at different developmental stages.European journal of immunology · 2016Article
- Downregulation of the phosphatase JKAP/DUSP22 in T cells as a potential new biomarker of systemic lupus erythematosus nephritis.Oncotarget · 2016Article
- Histone Deacetylase 3 Is Required for Efficient T Cell Development.Molecular and cellular biology · 2015Article
- [Construction of expression vector pLCK-CD69-IRES-EGFP and generation of CD69 transgenic mice].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2015Article
- FADD regulates thymocyte development at the β-selection checkpoint by modulating Notch signaling.Cell death & disease · 2014Article
- The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells.The Journal of biological chemistry · 2013Article
- A transgenic mouse model of human T cell leukemia virus type 1-associated diseases.Frontiers in microbiology · 2013Article
- Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology.Frontiers in immunology · 2013Article
- Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness.The Journal of clinical investigation · 2012Article
- Efnb1 and Efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling.The Journal of biological chemistry · 2011Article
- The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint.European journal of immunology · 2008Article
- Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors.Molecular and cellular biology · 2005Article
- Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes.The Journal of experimental medicine · 2005Article
- The role of LIGHT in T cell-mediated immunity.Immunologic research · 2004Review
- Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.The EMBO journal · 2003Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lck gene encodes a protein tyrosine kinase that participates in lymphocyte-specific signal transduction pathways. Previous studies have established that lck transcription is regulated by two distinct promoter elements termed proximal (or 3') and distal (or 5'). The proximal promoter is active almost exclusively in thymocytes and becomes inactive later during T-cell maturation. To dissect the mechanisms responsible for lck gene regulation, we generated transgenic animals bearing 5' truncations in the proximal promoter element. Sequences between -584 and +37 with respect to the proximal promoter transcription start site act to direct tissue-specific and temporally correct transcription of either a tagged version of the lck gene itself or a heterologous reporter sequence (lacZ). This region contains binding sites for at least five distinct nuclear proteins, of which one is found only in cells that support proximal lck promoter activity and a second appears only in nonexpressing cells. Interestingly, the transcribed region of the lck gene contains positive control elements that can substantially boost expression from minimal (-130 bp) proximal promoter constructs. These results provide a basis for the biochemical dissection of transcriptional regulators that act at defined points during T-cell development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.