ReviewJournal of industrial microbiology & biotechnology2005
New developments in the understanding of the cation diffusion facilitator family.
Review in Journal of industrial microbiology & biotechnology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 135 citations in OpenAlex.
- Integrated transcriptomic and hormonomic insights into cadmium tolerance of aMicrobiology (Reading, England) · 2026Article
- Bacteria Under Metal Stress-Molecular Mechanisms of Metal Tolerance.International journal of molecular sciences · 2025Review
- Dissecting the genetic architecture of polygenic nutritional traits in maize through meta-QTL analysis.Food chemistry. Molecular sciences · 2025Article
- Genomic characterisation of the metal tolerance protein gene family and elucidation of functional role in heavy metal tolerance and accumulation inFrontiers in plant science · 2025Article
- Biofortification of baby corn: Integrating agronomic and genetic approaches to address zinc micronutrient deficiencies - global perspectives and future challenges.Frontiers in plant science · 2025Review
- Genetic and biochemical determinants in potentially toxic metals resistance and plant growth promotion in Rhizobium sp LBMP-C04.World journal of microbiology & biotechnology · 2024Article
- Article
- Mechanisms of microbial resistance against cadmium - a review.Journal of environmental health science & engineering · 2024Review
- Genome-wide identification, expression and function analysis of theFrontiers in plant science · 2024Article
- Identification and Characterization of Dmct: A Cation Transporter inJournal of fungi (Basel, Switzerland) · 2023Article
- Identification and evolutionary analysis of the metal-tolerance protein family in eight Cucurbitaceae species.The plant genome · 2022Article
- From Copper Tolerance to Resistance inGenes · 2022Review
- Assessment ofFrontiers in microbiology · 2022Article
- Adaptive Evolution of Lactococcus Lactis to Thermal and Oxidative Stress Increases Biomass and Nisin Production.Applied biochemistry and biotechnology · 2021Article
- Comparative and Systematic Omics Revealed Low Cd Accumulation of PotatoInternational journal of molecular sciences · 2021Article
- Metal transport mechanism of the cation diffusion facilitator (CDF) protein family - a structural perspective on human CDF (ZnT)-related diseases.RSC chemical biology · 2021Review
- The metal binding site composition of the cation diffusion facilitator protein MamM cytoplasmic domain impacts its metal responsivity.Scientific reports · 2020Article
- Endomembrane Reorganization Induced by Heavy Metals.Plants (Basel, Switzerland) · 2020Review
- Genome-wide identification and characterization of the metal tolerance protein (MTP) family in grape (3 Biotech · 2019Article
- Implications for Cation Selectivity and Evolution by a Novel Cation Diffusion Facilitator Family Member From the Moderate HalophileFrontiers in microbiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cation diffusion facilitator (CDF) proteins are a phylogenetically ubiquitous family of intermembrane transporters generally believed to play a role in the homeostasis of a wide range divalent metal cations. CDFs are found in a host of membranes, including the bacterial cell membrane, the vacuolar membrane of both plants and yeast, and the golgi apparatus of animals. As such, they are potentially useful in the engineering of hyperaccumulative phytoremediation systems. While not yet sufficient for reliable biotechnological manipulation, characterization of this family is proceeding briskly. Experimental data suggests that CDFs are generally homodimers that use proton antiport to drive substrate translocation across a membrane. This translocation of both substrate and protons is likely mediated by a combination of histidines, aspartates, and glutamates. Functional data has suggested that CDFs are not limited to metal homeostasis roles, as some appear to be determinants in the operation of high-volume metal resistance systems, and others may facilitate cation-donation as a means of signal transduction. This review seeks to give an overview of the data prompting these conclusions, while presenting additional data whose interpretation is still contentious.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.