ArticlePediatric nephrology (Berlin, Germany)2005
Can azathioprine and steroids alter the progression of severe Henoch-Schönlein nephritis in children?
Article in Pediatric nephrology (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- The efficacy and safety of immunosuppressive agents plus steroids compared with steroids alone in the treatment of Henoch-Schönlein purpura nephritis: A meta-analysis.International urology and nephrology · 2019Pooled it
- Interventions for preventing and treating kidney disease in Henoch-Schönlein Purpura (HSP).The Cochrane database of systematic reviews · 2015Pooled it
- Cyclosporine A vs. methylprednisolone for Henoch-Schönlein nephritis: a randomized trial.Pediatric nephrology (Berlin, Germany) · 2011Trial
- Combined Therapy with Azathioprine, Prednisone, and Enalapril in Children with IgAN and IgAVN.Journal of clinical medicine · 2024Article
- Navigating Adult-Onset IgA Vasculitis-Associated Nephritis.Life (Basel, Switzerland) · 2024Review
- Steroid-Dependent Recurrent IgA Vasculitis in a 19-Year-Old Woman.HCA healthcare journal of medicine · 2024Article
- IgA vasculitis with nephritis: update of pathogenesis with clinical implications.Pediatric nephrology (Berlin, Germany) · 2022Review
- Bibliometric analysis of IgA vasculitis nephritis in children from 2000 to 2022.Frontiers in public health · 2022Article
- IgA Vasculitis in Adults: a Rare yet Challenging Disease.Current rheumatology reports · 2021Review
- Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis.BMJ case reports · 2021Article
- Onset age is a risk factor for refractory pediatric IgA vasculitis: a retrospective cohort study.Pediatric rheumatology online journal · 2020Article
- Does MEST-C score predict outcomes in pediatric Henoch-Schönlein purpura nephritis?Pediatric nephrology (Berlin, Germany) · 2019Article
- The significance of tubulointerstitial lesions in childhood Henoch-Schönlein nephritis.Pediatric nephrology (Berlin, Germany) · 2016Article
- Azathioprine therapy for steroid-resistant Henoch-Schönlein purpura: a report of 6 cases.Pediatric rheumatology online journal · 2016Article
- Treatment of children with Henoch-Schönlein purpura nephritis with mycophenolate mofetil.Pediatric nephrology (Berlin, Germany) · 2012Article
- Improved outcome of Henoch-Schonlein purpura nephritis by early intensive treatment.Indian journal of pediatrics · 2012Article
- Early treatment with methylprednisolone pulse therapy combined with tonsillectomy for heavy proteinuric henoch-schönlein purpura nephritis in children.Nephron extra · 2011Article
- Henoch-Schönlein purpura in childhood: treatment and prognosis. Analysis of 425 cases over a 5-year period.Clinical rheumatology · 2010Article
- Treatment-based literature of Henoch-Schönlein purpura nephritis in childhood.Pediatric nephrology (Berlin, Germany) · 2009Review
- Treatment of severe Henoch-Schönlein and immunoglobulin A nephritis. A single center experience.Pediatric nephrology (Berlin, Germany) · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the effect of azathioprine with steroids on the clinical course and histologic parameters of severe Henoch-Schönlein nephritis (HSN), 20 patients with a median age of 9.3 years (range 4.4-17 years) and a follow-up period of 4.8 years (range 1-14 years) were included in this study. The patients were divided into two groups. Ten patients received azathioprine with steroids for 8 months (group A), and the other ten received steroids alone (group B). All patients underwent renal biopsy at presentation, and ten of them who were treated with azathioprine underwent follow-up biopsy after therapy. Six patients in group A achieved clinical remission, and the remaining four showed minor urinary abnormalities at the latest observation. The histological grades of the International Study of Kidney Disease in Children (ISKDC) improved in four of the ten patients, and the activity index decreased significantly from 6.8+/-2.0 to 4.3+/-2.3 (p=0.016). In group B, however, four patients had normal urine and renal function; two had minor urinary abnormalities; one had active renal disease, and three had chronic renal insufficiency, at the latest observation. The combination treatment of azathioprine and steroids may be beneficial in ameliorating histopathological features and improving the clinical course of severe HSN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.