ReviewPediatric nephrology (Berlin, Germany)2005
Mechanisms of renal damage owing to infection.
Review in Pediatric nephrology (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Genetic susceptibility to renal scar formation after urinary tract infection: a systematic review and meta-analysis of candidate gene polymorphisms.Pediatric nephrology (Berlin, Germany) · 2011Pooled it
- The effect of vitamin E or vitamin A on the prevention of renal scarring in children with acute pyelonephritis.Pediatric nephrology (Berlin, Germany) · 2013Trial
- The impact of therapeutic delay time on acute scintigraphic lesion and ultimate scar formation in children with first febrile UTI.European journal of pediatrics · 2012Trial
- Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial.BMJ (Clinical research ed.) · 2007Trial
- Multifunctional VEGF/CeOPharmaceutics · 2026Article
- Plasma and Urinary Neutrophil Gelatinase-Associated Lipocalin as Predictors of Renal Parenchymal Involvement in Children with Febrile Urinary Tract Infection: A Pilot Study.Children (Basel, Switzerland) · 2024Article
- The Association between Influenza Vaccine and Risk of Chronic Kidney Disease/Dialysis in Patients with Hypertension.Vaccines · 2023Article
- Antimicrobial misuse in pediatric urinary tract infections: recurrences and renal scarring.Annals of clinical microbiology and antimicrobials · 2018Article
- Urinary matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 biomarkers for predicting renal scar in children with urinary tract infection.Turkish journal of urology · 2017Article
- Estimation of the relationship between the polymorphisms of selected genes: ACE, AGTR1, TGFβ1 and GNB3 with the occurrence of primary vesicoureteral reflux.International urology and nephrology · 2017Article
- Strengths and Limitations of Model Systems for the Study of Urinary Tract Infections and Related Pathologies.Microbiology and molecular biology reviews : MMBR · 2016Review
- Acute focal bacterial nephritis, pyonephrosis and renal abscess in children.Pediatric nephrology (Berlin, Germany) · 2015Article
- Urinary neutrophil gelatinase-associated lipocalin (NGAL) might be an independent marker for anticipating scar formation in children with acute pyelonephritis.Journal of renal injury prevention · 2015Article
- TLR-4 polymorphisms and leukocyte TLR-4 expression in febrile UTI and renal scarring.Pediatric nephrology (Berlin, Germany) · 2013Article
- Article
- Renal scar formation after urinary tract infection in children.Korean journal of pediatrics · 2012Article
- Acinetobacter calcoaceticus-baumannii complex strains induce caspase-dependent and caspase-independent death of human epithelial cells.Current microbiology · 2012Article
- Vitamin D receptor gene polymorphism in children with urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2012Article
- Urinary tract infections in children: recommendations for antibiotic prophylaxis and evaluation. An evidence-based approach.Current urology reports · 2010Review
- Diaper type as a risk factor in urinary tract infection of children.Iranian journal of pediatrics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary tract infection (UTI) is a common bacterial illness in children. It is known to be associated with an increased risk of permanent renal cell damage and scarring which may lead to generation of pathological conditions such as hypertension, pre-eclampsia during pregnancy, renal insufficiency, and end-stage kidney disease. The pathophysiology of renal scarring is still obscure, which makes the prevention of renal damage difficult. During acute infection, there are numerous factors that may contribute to tissue damage. Inflammatory responses are activated by host defense mechanisms as well as by specific bacterial virulence factors. Understanding of these complex mechanisms would be helpful to better identify children at high risk of developing renal scarring following UTI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.