ArticleGenes and immunity2005
Family-based association analysis implicates IL-4 in susceptibility to Kawasaki disease.
Article in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
- Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study.PloS one · 2012Trial
- Kawasaki Disease: Unraveling Immunopathogenesis, Genetic Factors, and AI Applications in Diagnosis with a Focus on Iran.Pediatric cardiology · 2026Review
- Pharmacogenomics of coronary artery response to intravenous gamma globulin in kawasaki disease.NPJ genomic medicine · 2024Article
- Basophils Predict Mite Sensitization in Patients with Kawasaki Disease.Children (Basel, Switzerland) · 2023Article
- Pharmacogenomics of intravenous immunoglobulin response in Kawasaki disease.Frontiers in immunology · 2023Article
- Kawasaki Disease and Allergic Diseases.Frontiers in pediatrics · 2020Review
- Kawasaki Disease: The Role of Immune Complexes Revisited.Frontiers in immunology · 2019Review
- Biomarkers for Kawasaki Disease: Clinical Utility and the Challenges Ahead.Frontiers in pediatrics · 2019Review
- Clinical Outcomes of Low-Dose Methotrexate Therapy as a Second-Line Drug for Intravenous Immunoglobulin-Resistant Kawasaki Disease.Yonsei medical journal · 2018Article
- Risk factors and implications of progressive coronary dilatation in children with Kawasaki disease.BMC pediatrics · 2017Article
- Association of Attention deficit hyperactivity disorder and Kawasaki disease: a nationwide population-based cohort study.Epidemiology and psychiatric sciences · 2016Article
- Gene-Gene Associations with the Susceptibility of Kawasaki Disease and Coronary Artery Lesions.PloS one · 2015Article
- Distribution and Protective Role of HLAB40 in Iranian Patients with Kawasaki Disease; a Report from Southern Iran.Iranian journal of pediatrics · 2014Article
- Association between Kawasaki disease and autism: a population-based study in Taiwan.International journal of environmental research and public health · 2014Article
- Kawasaki disease and subsequent risk of allergic diseases: a population-based matched cohort study.BMC pediatrics · 2013Article
- Increased risk of atopic dermatitis in preschool children with kawasaki disease: a population-based study in taiwan.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Understanding the pathogenesis of Kawasaki disease by network and pathway analysis.Computational and mathematical methods in medicine · 2013Review
- Comparison of the laboratory data between Kawasaki disease and enterovirus after intravenous immunoglobulin treatment.Pediatric cardiology · 2012Article
- Elevated Serum Levels of IL-21 in Kawasaki Disease.Allergy, asthma & immunology research · 2012Article
- Genetic polymorphisms in Kawasaki disease.Acta pharmacologica Sinica · 2011Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Several compelling lines of evidence suggest an important influence of genetic variation in susceptibility to Kawasaki disease (KD), an acute vasculitis that causes coronary artery aneurysms in children. We performed a family-based genotyping study to test for association between KD and 58 genes involved in cardiovascular disease and inflammation. By analysis of a cohort of 209 KD trios using the transmission disequilibrium test, we documented the asymmetric transmission of five alleles including the interleukin-4 (IL-4) C(-589)T allele (P=0.03). Asymmetric transmission of the IL-4 C(-589)T was replicated in a second, independent cohort of 60 trios (P=0.05, combined P=0.002). Haplotypes of alleles in IL-4, colony-stimulating factor 2 (CSF2), IL-13, and transcription factor 7 (TCF7), all located in the interleukin gene cluster on 5q31, were also asymmetrically transmitted. The reported associations of KD with atopic dermatitis and allergy, elevated serum IgE levels, eosinophilia, and increased circulating numbers of monocyte/macrophages expressing the low-affinity IgE receptor (FCepsilonR2) may be related to effects of IL-4. Thus, the largest family-based genotyping study of KD patients to date suggests that genetic variation in the IL-4 gene, or regions linked to IL-4, plays an important role in KD pathogenesis and disease susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.