ArticleMolecular & general genetics : MGG1992
The lysozyme locus in Drosophila melanogaster: different genes are expressed in midgut and salivary glands.
Article in Molecular & general genetics : MGG, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Anatomy and Physiology of the Digestive Tract ofGenetics · 2018Review
- Isolation, characterization, kinetics, and enzymatic and nonenzymatic microbicidal activities of a novel c-type lysozyme from plasma of Schistocerca gregaria (Orthoptera: Acrididae).Journal of insect science (Online) · 2015Article
- Article
- Gene expression in gut symbiotic organ of stinkbug affected by extracellular bacterial symbiont.PloS one · 2013Article
- Evolution of the mammalian lysozyme gene family.BMC evolutionary biology · 2011Article
- Article
- Lysozymes in the animal kingdom.Journal of biosciences · 2010Review
- Digestive function of lysozyme in synanthropic acaridid mites enables utilization of bacteria as a food source.Experimental & applied acarology · 2008Article
- Asymmetric sequence divergence of duplicate genes.Genome research · 2003Article
- Malaria infection of the mosquito Anopheles gambiae activates immune-responsive genes during critical transition stages of the parasite life cycle.The EMBO journal · 1998Article
- Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes.The EMBO journal · 1997Article
- Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Immune responsiveness in vector insects.Proceedings of the National Academy of Sciences of the United States of America · 1997Review
- Regional expression of the transcript encoding sterol carrier protein x-related thiolase and its regulation by homeotic genes in the midgut of Drosophila embryos.Development, growth & differentiation · 1996Article
- The lysozyme locus in Drosophila melanogaster: an expanded gene family adapted for expression in the digestive tract.Molecular & general genetics : MGG · 1994Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As part of a study of the genes involved in antibacterial defense in Drosophila melanogaster, we have isolated genomic clones harboring a family of chicken-type lysozyme genes, using a lepidopteran lysozyme cDNA as probe. The locus was mapped to the cytological location 61F1-4 on the third chromosome and two of the genes at this locus, LysD and LysP, were analyzed in detail. In contrast to the bacteria-induced lysozymes in the hemolymph of many insects, the transcription levels of both Drosophila genes decrease after bacterial injections into the hemocoel. Apparently, these gene products, like the specifically adapted lysozymes in mammalian foregut fermenters, have been recruited for the digestion of bacteria present in fermenting food. The LysD gene is expressed in an anterior section of the midgut during all feeding stages of development in both larvae and adults. The LysP gene is only active in the adult where it is expressed in the salivary glands. The transcription units for both genes are very compact and they lack introns. Lysozyme D is unusual in that it is predicted to have an acidic isoelectric point whereas lysozyme P appears to be a typical basic lysozyme.
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Registered trials
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