ArticleGut2005
Gut mucosal granulocyte activation precedes nitric oxide production: studies in coeliac patients challenged with gluten and corn.
Article in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Beyond the Gut: Brain Fog, Sleep Quality, Cognitive Function and Quality of Life in Celiac Disease.Nutrients · 2026Observational
- The Prevalence of Anti-Zein Antibodies: A Comparative Study between Celiac Disease and Irritable Bowel Syndrome.Nutrients · 2021Article
- Navigating the Gluten-Free Boom: The Dark Side of Gluten Free Diet.Frontiers in pediatrics · 2019Review
- Gliadin Induces Neutrophil Migration via Engagement of the Formyl Peptide Receptor, FPR1.PloS one · 2015Article
- Maize prolamins could induce a gluten-like cellular immune response in some celiac disease patients.Nutrients · 2013Review
- The sourdough fermentation may enhance the recovery from intestinal inflammation of coeliac patients at the early stage of the gluten-free diet.European journal of nutrition · 2012Article
- Maize prolamins resistant to peptic-tryptic digestion maintain immune-recognition by IgA from some celiac disease patients.Plant foods for human nutrition (Dordrecht, Netherlands) · 2012Article
- Article
- Cow's milk protein sensitivity assessed by the mucosal patch technique is related to irritable bowel syndrome in patients with primary Sjögren's syndrome.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2008Article
- Proteins specifically hyperexpressed in a coeliac disease patient with aberrant T cells.Clinical and experimental immunology · 2007Article
- Mucosal reactivity to cow's milk protein in coeliac disease.Clinical and experimental immunology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsTo elucidate the dynamics of nitric oxide (NO) production induced by rectal gluten challenge and the relation between NO production and mucosal granulocyte activation. SUBJECTS AND
methodsRelease of rectal NO was measured in 13 patients with coeliac disease and in 18 controls before and after rectal wheat gluten challenge. Rectal gas was collected with a rectal balloon using a newly developed instrument/technique, the "mucosal patch technique". The instrument allows simultaneous measurements of concentrations of granulocyte mediators in the rectal mucosa. We measured myeloperoxidase (MPO), eosinophil cationic protein (ECP), and histamine. For comparison, we made similar measurements after corn (maize) gluten challenge.
resultsIn all coeliac patients rectal NO concentration increased after gluten challenge and reached a peak after 15 hours (mean 9464 (SEM 2393) parts per billion (ppb); range 250-24982). The maximum MPO and ECP increase occurred five hours after challenge. A correlation was found between mucosal MPO and NO production at 15 hours. Six of the patients showed an increase in NO production 15 hours after rectal corn gluten challenge but this was much smaller than after gluten challenge. No increases were seen in the control group after either challenge.
conclusionMucosal activation of neutrophils and eosinophils precedes pronounced enhancement of mucosal NO production after rectal wheat gluten challenge in patients with coeliac disease. Some of our coeliac patients displayed signs of an inflammatory reaction, as measured by NO and granulocyte markers, after rectal corn gluten challenge.
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