ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
GABA type-A activity controls its own developmental polarity switch in the maturing retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 76 citations in OpenAlex.
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- Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity.Frontiers in molecular neuroscience · 2021Article
- Dystrophin Is Required for the Proper Timing in Retinal Histogenesis: A Thorough Investigation on theFrontiers in neuroscience · 2020Article
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- Slow-release drug delivery through Elvax 40W to the rat retina: implications for the treatment of chronic conditions.Journal of visualized experiments : JoVE · 2014Article
- Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse.The Journal of physiology · 2014Article
- Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2.Frontiers in cellular neuroscience · 2014Review
- The neurobiology of opiate motivation.Cold Spring Harbor perspectives in medicine · 2012Review
- Effects of third trimester-equivalent ethanol exposure on Cl(-) co-transporter expression, network activity, and GABAergic transmission in the CA3 hippocampal region of neonatal rats.Alcohol (Fayetteville, N.Y.) · 2012Article
- Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!Frontiers in cellular neuroscience · 2012Article
- Coordinated increase in inhibitory and excitatory synapses onto retinal ganglion cells during development.Neural development · 2011Article
- Development of cortical GABAergic innervation.Frontiers in cellular neuroscience · 2011Article
- Non-cell-autonomous factor induces the transition from excitatory to inhibitory GABA signaling in retina independent of activity.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Phenotypic checkpoints regulate neuronal development.Trends in neurosciences · 2010Article
- Development of light response and GABAergic excitation-to-inhibition switch in zebrafish retinal ganglion cells.The Journal of physiology · 2010Article
- Mechanisms underlying spontaneous patterned activity in developing neural circuits.Nature reviews. Neuroscience · 2010Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the developing CNS, GABA(A) responses switch from early excitation to late mature inhibition. The developmental factors that induce the polarity switch remain to be unraveled. Here, we bring the first experimental evidence in vivo in the retina that chronic activation of GABA(A) receptors is necessary for the switch to occur and for the chloride extrusion mechanism (through the K+/Cl- cotransporter KCC2) to develop. Using a turtle model and calcium imaging, we investigated how chronic blockade of GABA(A) receptors with bicuculline during the period of the GABAergic polarity switch (from 1 week before hatching until 4 weeks after hatching) influences developmental changes in the patterns of spontaneously generated electrical activity in the retinal ganglion cell (RGC) layer. During that period, spontaneous activity normally switches from propagating waves to stationary patches of coactive cells, until correlated activity completely disappears. These changes in activity patterns coincide with the switch of GABA(A) responses from excitation to inhibition. When GABA(A) receptors are chronically blocked, GABA(A) responses remain excitatory and spontaneous waves keep propagating across the RGC layer. Concomitantly, the developmental upregulation of KCC2 is inhibited on dendritic processes in the inner plexiform layer, suggesting that the intracellular concentration of chloride remains higher, as in younger cells. This study presents the first demonstration in vivo that GABA autoregulates its developmental polarity switch, emphasizing the importance of GABAergic activity in controlling activity patterns in the maturing retina.
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