ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed.
- Spinal Processing of Spatiotemporally Diverse Tactile Stimuli: Computational Insights into Allodynia and Spinal Cord Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dendritic synaptic integration modes under in vivo-like states.Biophysical journal · 2025Article
- An electrophysiologist's guide to dorsal horn excitability and pain.Frontiers in cellular neuroscience · 2025Review
- Noise or signal? Spontaneous activity of dorsal horn neurons: patterns and function in health and disease.Pflugers Archiv : European journal of physiology · 2024Review
- Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I.Frontiers in synaptic neuroscience · 2023Article
- Central and peripheral contributions of T-type calcium channels in pain.Molecular brain · 2022Review
- Article
- Origin and classification of spontaneous discharges in mouse superficial dorsal horn neurons.Scientific reports · 2018Article
- Origin of heterogeneous spiking patterns from continuously distributed ion channel densities: a computational study in spinal dorsal horn neurons.The Journal of physiology · 2018Article
- Non-Decaying postsynaptics potentials and delayed spikes in hippocampal pyramidal neurons generated by a zero slope conductance created by the persistent NaChannels (Austin, Tex.) · 2018Article
- A Negative Slope Conductance of the Persistent Sodium Current Prolongs Subthreshold Depolarizations.Biophysical journal · 2017Article
- The role of negative conductances in neuronal subthreshold properties and synaptic integration.Biophysical reviews · 2017Review
- Article
- Near-Perfect Synaptic Integration by Nav1.7 in Hypothalamic Neurons Regulates Body Weight.Cell · 2016Article
- Motor Cortex Excitability and BDNF Levels in Chronic Musculoskeletal Pain According to Structural Pathology.Frontiers in human neuroscience · 2016Article
- Activation of Ih and TTX-sensitive sodium current at subthreshold voltages during CA1 pyramidal neuron firing.Journal of neurophysiology · 2015Article
- Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control.Journal of neurophysiology · 2015Article
- Coding of envelopes by correlated but not single-neuron activity requires neural variability.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Pacemaker Neurons and the Development of Nociception.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Subthreshold membrane currents confer distinct tuning properties that enable neurons to encode the integral or derivative of their input.Frontiers in cellular neuroscience · 2014Article
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2 authors.
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Abstract
Lamina I of the spinal dorsal horn plays an important role in processing and relaying nociceptive information to the brain. It comprises physiologically distinct cell types that process information in fundamentally different ways: tonic neurons fire repetitively during stimulation and display prolonged EPSPs, suggesting operation as integrators, whereas single-spike neurons act like coincidence detectors. Using whole-cell recordings from a rat spinal slice preparation, we set out to determine the basis for prolonged EPSPs in tonic cells and the implications for signal processing. Kinetics of synaptic currents could not explain differences in EPSP kinetics. Instead, tonic neurons were found to express a persistent sodium current, I(Na,P), that amplified and prolonged depolarization in response to brief stimulation. Tonic neurons also expressed a persistent calcium current, I(Ca,P), that contributed to prolongation but not to amplification. Simulations using NEURON software demonstrated that I(Na,P) was necessary and sufficient to explain amplification, whereas I(Na,P) and I(Ca,P) acted synergistically to prolong depolarization: initial activation of the slower current (I(Ca,P)) depended on the faster current (I(Na,P)) but maintained activation of the faster current likewise depended on the slower current. Additional investigation revealed that I(Na,P) and I(Ca,P) could dramatically increase integration time (>30x) and thereby encourage temporal summation but at the expense of spike time precision. Thus, by prolonging subthreshold depolarization, intrinsic inward currents allow tonic neurons in spinal lamina I to specialize as integrators that are optimally suited to encode stimulus intensity.
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