ArticleProceedings. Biological sciences2005
A comparative analysis of the evolutionary relationship between diet and enzyme targeting in bats, marsupials and other mammals.
Article in Proceedings. Biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Convergent evolutionary shifts in AGT targeting between mitochondria and peroxisomes across mammal transitions to herbivory.Nature communications · 2026Article
- Structural and evolutionary constraints shape adaptive landscapes of immune-related genes across mammalian phylogeny.PloS one · 2025Article
- Catabolism of Hydroxyproline in Vertebrates: Physiology, Evolution, Genetic Diseases and New siRNA Approach for Treatment.International journal of molecular sciences · 2022Review
- Dysfunctional peroxisomal lipid metabolisms and their ocular manifestations.Frontiers in cell and developmental biology · 2022Review
- Review
- Urinary oxalate to creatinine ratios in healthy Turkish schoolchildren.Renal failure · 2017Article
- Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae).PloS one · 2016Article
- Primary hyperoxalurias: diagnosis and treatment.Pediatric nephrology (Berlin, Germany) · 2015Review
- Relaxed evolution in the tyrosine aminotransferase gene tat in old world fruit bats (Chiroptera: Pteropodidae).PloS one · 2014Article
- Protein homeostasis defects of alanine-glyoxylate aminotransferase: new therapeutic strategies in primary hyperoxaluria type I.BioMed research international · 2013Review
- Genome and transcriptome analyses provide insight into the euryhaline adaptation mechanism of Crassostrea gigas.PloS one · 2013Article
- Primary hyperoxaluria type III--a model for studying perturbations in glyoxylate metabolism.Journal of molecular medicine (Berlin, Germany) · 2012Article
- Predicted mouse peroxisome-targeted proteins and their actual subcellular locations.BMC bioinformatics · 2008Article
- The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis.Journal of insect physiology · 2007Article
- Evolution of two alanine glyoxylate aminotransferases in mosquito.The Biochemical journal · 2006Article
- Lifestyle, genetics, and disease in Sami.Croatian medical journal · 2006Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subcellular distribution of the enzyme alanine:glyoxylate aminotransferase (AGT) in the livers of different mammals appears to be related to their natural diets. Thus, AGT tends to be mitochondrial in carnivores, peroxisomal in herbivores, and both mitochondrial and peroxisomal in omnivores. To what extent this relationship is an incidental consequence of phylogenetic structure or an evolutionarily meaningful adaptive response to changes in dietary selection pressure is unknown. In order to distinguish between these two possibilities, we have determined the subcellular distribution of AGT in the livers of 22 new mammalian species, including members of three orders not studied before. In addition, we have analysed the statistical relationship between AGT distribution and diet in all 77 mammalian species, from 12 different orders, for which the distribution is currently known. Our analysis shows that there is a highly significant correlation between AGT distribution and diet, independent of phylogeny. This finding is compatible with the suggestion that the variable intracellular targeting of AGT is an adaptive response to episodic changes in dietary selection pressure. To our knowledge, this is the first example of such a response being manifested at the molecular and cellular levels across the breadth of Mammalia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.