ReviewJournal of mammary gland biology and neoplasia2005
Stem/progenitor cells in mouse mammary gland development and breast cancer.
Review in Journal of mammary gland biology and neoplasia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
- High-throughput profiling of histone post-translational modifications and chromatin modifying proteins by reverse phase protein array.Journal of proteomics · 2022Article
- IGF1R constitutive activation expands luminal progenitors and influences lineage differentiation during breast tumorigenesis.Developmental biology · 2020Article
- Regulatory T Cells Control the Switch FromFrontiers in immunology · 2019Article
- Article
- Leptin and Adiponectin Modulate the Self-renewal of Normal Human Breast Epithelial Stem Cells.Cancer prevention research (Philadelphia, Pa.) · 2015Article
- Krt6a-positive mammary epithelial progenitors are not at increased vulnerability to tumorigenesis initiated by ErbB2.PloS one · 2015Article
- Cancer Stem and Progenitor-Like Cells as Pharmacological Targets in Breast Cancer Treatment.Breast cancer : basic and clinical research · 2015Review
- Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype.PloS one · 2014Article
- Article
- Atbf1 regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogen-ER signaling.PloS one · 2012Article
- Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation.Cancer prevention research (Philadelphia, Pa.) · 2012Article
- Article
- Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy.Science translational medicine · 2010Article
- Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells.PloS one · 2010Article
- Ras activation contributes to the maintenance and expansion of Sca-1pos cells in a mouse model of breast cancer.Cancer letters · 2010Article
- RARα1 control of mammary gland ductal morphogenesis and wnt1-tumorigenesis.Breast cancer research : BCR · 2010Article
- Article
- Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice.Neoplasia (New York, N.Y.) · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Breast cancer is a genetically and clinically heterogeneous disease. It is unclear whether different target cells contribute to this heterogeneity and which cell types are most susceptible to oncogenesis. Stem cells are speculated to be the cellular origin of at least a subset of human breast cancers. To begin to address these issues, we have isolated and characterized cell populations enriched in normal mammary stem/progenitors and have studied the expression of putative stem/progenitor markers in tumors derived from genetically engineered mice. Specifically, transgenic activation of Wnt signaling in the mammary gland induces tumors comprised of epithelial and myoepithelial cells harboring the same genetic defect implying that the tumor arose from transformation of a bipotent progenitor cell. On the other hand, transgenic activation of Neu signaling induces tumors comprising cells of more limited lineage capacity. Thus, the heterogeneity of different breast cancers may reflect the activation of different oncogenic pathways, different cellular targets in which these genetic changes occur, or both.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.