ArticleCurrent biology : CB2005
fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses.
Article in Current biology : CB, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.PLoS genetics · 2013Pooled it
- The genetics of situs inversus without primary ciliary dyskinesia.Scientific reports · 2020Trial
- Asymmetrical modulation of fear expression via GABAProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Zebrafish larva interface: an accessible, modular platform forFrontiers in neuroscience · 2025Article
- Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization.Frontiers in behavioral neuroscience · 2025Review
- Handedness in Animals and Plants.Biology · 2024Article
- Responses in the left and right entopallium are differently affected by light stimulation in embryo.iScience · 2024Article
- Valproic acid exposure affects social visual lateralization and asymmetric gene expression in zebrafish larvae.Scientific reports · 2024Article
- Light-induced asymmetries in embryonic retinal gene expression are mediated by the vascular system and extracellular matrix.Scientific reports · 2022Article
- Disruption of left-right axis specification in Ciona induces molecular, cellular, and functional defects in asymmetric brain structures.BMC biology · 2021Article
- Molecular and cellular determinants of motor asymmetry in zebrafish.Nature communications · 2020Article
- Brain and Behavioral Asymmetry: A Lesson From Fish.Frontiers in neuroanatomy · 2020Review
- Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses.Animal cognition · 2019Article
- Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains.Scientific reports · 2018Article
- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- Asymmetric development of the nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Left-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis.Trends in genetics : TIG · 2017Review
- Exposure to agricultural pesticide impairs visual lateralization in a larval coral reef fish.Scientific reports · 2017Article
- Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases.Genes · 2017Review
- Nodal signalling and asymmetry of the nervous system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
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Abstract
Asymmetries in CNS neuroanatomy are assumed to underlie the widespread cognitive and behavioral asymmetries in vertebrates. Studies in humans have shown that the laterality of some cognitive asymmetries is independent of the laterality of the viscera; discrete mechanisms may therefore regulate visceral and neural lateralization. However, through analysis of visceral, neuroanatomical, and behavioral asymmetries in the frequent-situs-inversus (fsi) line of zebrafish, we show that the principal left-right body asymmetries are coupled to certain brain asymmetries and lateralized behaviors. fsi fish with asymmetry defects show concordant reversal of heart, gut, and neuroanatomical asymmetries in the diencephalon. Moreover, the neuroanatomical reversals in reversed fsi fish correlate with reversal of some behavioral responses in both fry and adult fsi fish. Surprisingly, two behavioral asymmetries do not reverse, suggesting that at least two separable mechanisms must influence functional lateralization in the CNS. Partial reversal of CNS asymmetries may generate new behavioral phenotypes; supporting this idea, reversed fsi fry differ markedly from their normally lateralized siblings in their behavioral response to a novel visual feature. Revealing a link between visceral and brain asymmetry and lateralized behavior, our studies help to explain the complexity of the relationship between the lateralities of visceral and neural asymmetries.
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