ArticleImmunology2005
Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis.
Article in Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- B cells promote granulomatous inflammation during chronic Mycobacterium tuberculosis infection in mice.PLoS pathogens · 2023Article
- Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.European journal of immunology · 2016Article
- The role of B cells and humoral immunity in Mycobacterium tuberculosis infection.Seminars in immunology · 2014Review
- Tissue-specific effector functions of innate lymphoid cells.Immunology · 2013Review
- Clonal expansions of CD8+ T cells with IL-10 secreting capacity occur during chronic Mycobacterium tuberculosis infection.PloS one · 2013Article
- The role of B cells and humoral immunity in Mycobacterium tuberculosis infection.Advances in experimental medicine and biology · 2013Review
- Article
- Emerging trends in the formation and function of tuberculosis granulomas.Frontiers in immunology · 2012Article
- Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens.Infection and immunity · 2011Review
- How B cells shape the immune response against Mycobacterium tuberculosis.European journal of immunology · 2009Review
- Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infection.European journal of immunology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Mice on the CBA inbred strain background expressing the well characterized mutation designated xid in the cytoplasmic signalling enzyme Bruton's protein kinase have been previously noted to illustrate shifts in T helper type 1 (Th1)/Th2 immunity which is underlined by an apparent failure to produce the regulatory cytokine interleukin-10. In the current study we examined if this extended to infection with Mycobacterium tuberculosis, which also depends on Th1 immunity. Contrary to expectations, xid mice showed evidence of a transient early susceptibility to pulmonary infection, changes in macrophage morphology, and decreased activation of lung natural killer cells, while showing evidence of substantial IL-10 production and accumulation in lung lesions macrophages, but paradoxically this did not influence the course of the chronic disease. In addition, macrophages from the lungs of xid mice also expressed high levels of CD14. These observations suggest that the xid mutation in cellular signalling has much wider effects on the immune system than previously thought.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.